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dc.contributor.author
Garello, Francesca
dc.contributor.author
Arena, Francesca
dc.contributor.author
Cutrin, Juan Carlos
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dc.contributor.author
Esposito, Giovanna
dc.contributor.author
D'angeli, Luca
dc.contributor.author
Cesano, Federico
dc.contributor.author
Filippi, Miriam
dc.contributor.author
Figueiredo, Sara
dc.contributor.author
Terreno, Enzo
dc.date.available
2016-11-01T21:35:05Z
dc.date.issued
2015-05
dc.identifier.citation
Garello, Francesca; Arena, Francesca; Cutrin, Juan Carlos; Esposito, Giovanna; D'angeli, Luca; et al.; Glucan particles loaded with a NIRF agent for imaging monocytes/macrophages recruitment in a mouse model of rheumatoid arthritis; Royal Society of Chemistry; RSC Advances; 5; 43; 5-2015; 34078-34087
dc.identifier.issn
2046-2069
dc.identifier.uri
http://hdl.handle.net/11336/7913
dc.description.abstract
Glucan Particles (GPs) are hollow pseudo-microspheres (average diameter 3?5 mm) obtained from common baker´s yeast Saccharomyces cerevisiae, in which mannan, lipids and proteins are removed through a process of chemical extraction. GPs shell is mostly made of 1,3-b-D-glucan that allows for their prompt in vivo uptake by immune system cells. In this work, the inner cavity of the particles has been loaded with two amphiphilic fluorescent dyes (based on cyanine for in vivo imaging purposes and rhodamine for ex vivo microscopy experiments) through a sudden change in solvent polarity that allowed the entrapment of the molecules as microemulsion. The ability of fluorescent GPs to label immune cells in vivo and report on their recruitment in inflamed sites has been successfully demonstrated in a mouse model of rheumatoid arthritis (CIA) by NIRF imaging. Besides providing the visualization of the mononuclear cell infiltration in the lesion, the fluorescent signal well correlated with the clinical score associated with the disease. Very interestingly, the signal detected in lesions with the same clinical score allowed the assessment of the time evolution (progression or remission) of the pathology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Glucan Nanoparticles
dc.subject
Molecular Imaging
dc.subject
Inflammation
dc.subject.classification
Biomateriales
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Glucan particles loaded with a NIRF agent for imaging monocytes/macrophages recruitment in a mouse model of rheumatoid arthritis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-30T17:12:18Z
dc.journal.volume
5
dc.journal.number
43
dc.journal.pagination
34078-34087
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Garello, Francesca. Universitã â Di Torino; Italia
dc.description.fil
Fil: Arena, Francesca. Universitã â Di Torino; Italia
dc.description.fil
Fil: Cutrin, Juan Carlos. Universitã â Di Torino; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Esposito, Giovanna. Universita di Torino; Italia
dc.description.fil
Fil: D'angeli, Luca. University Of London; Reino Unido
dc.description.fil
Fil: Cesano, Federico. Universita di Torino; Italia
dc.description.fil
Fil: Filippi, Miriam. Universitã â Di Torino; Italia
dc.description.fil
Fil: Figueiredo, Sara. Universitã â Di Torino; Italia. Universidad de Coimbra; Portugal
dc.description.fil
Fil: Terreno, Enzo. Universita di Torino; Italia
dc.journal.title
RSC Advances
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra00720h#!divAbstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/C5RA00720H
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