Artículo
Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats
Oyhenart, Evelia Edith
; Cesani Rossi, María Florencia
; Castro, Luis Eduardo; Quintero, Fabian Anibal; Fucini, Maria Cecilia; Luna, María Eugenia; Guimarey, Luis Manuel
Fecha de publicación:
09/2011
Editorial:
Springer
Revista:
Anatomical Science International
ISSN:
1447-6959
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This paper addresses the effect of a reduction of uterine blood flow (RUB) on postcranial bone growth in rats. The objectives were: (1) to discover and characterize the changes evoked by growth retardation through a reduction in placental blood flow, (2) to see if the resulting growth retardation is different in each bone, and (3) to analyze any sex-specific features. RUB was induced by the partial bending of uterine vessels at day 1 of pregnancy. Control and sham-operated animals were also included. The animals were X-rayed at birth. The lengths and widths of the humerus, radius, and femur and pelvic length, interischial, interpubic, and pubic widths were measured. Data were analyzed by ANOVA and LSD post hoc tests. The intersubject analysis showed significant differences between groups and non-significant differences between sexes. In males, sham-operated and RUB showed significant differences in pelvic lengths and widths, and humeral, radial, femoral, and tibial widths. In females, there were significant differences only for humeral widths, radial lengths and widths, and femoral and tibial widths. We conclude that reduced blood flow delays appendicular bone growth as observed at birth. Pelvic length was more affected than that of the limbs. The widths of the pelvic and limbs bones, in turn, were more altered than the lengths, and the growth of the males more than that of the females. Partial bending of uterine vessels compromised postcranial growth, though under such disadvantageous circumstances the females proved to be more capable of growing and thus more resilient than the males.
Palabras clave:
Bone Growth
,
Intrauterine Growth Retardation
,
Sexual Dimorphism
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Identificadores
Colecciones
Articulos(IGEVET)
Articulos de INST.DE GENETICA VET ING FERNANDO NOEL DULOUT
Articulos de INST.DE GENETICA VET ING FERNANDO NOEL DULOUT
Citación
Oyhenart, Evelia Edith; Cesani Rossi, María Florencia; Castro, Luis Eduardo; Quintero, Fabian Anibal; Fucini, Maria Cecilia; et al.; Bone growth and sexual dimorphism at birth in intrauterine-growth-retarded rats; Springer; Anatomical Science International; 86; 3; 9-2011; 119-127
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