Artículo
Renal dopaminergic system: pathophysiological implications and clinical perspectives
Choi, Marcelo Roberto
; Kouyoumdzian, Nicolás Martín
; Rukavina Mikusic, Natalia Lucía
; Kravetz, Maria Cecilia; Roson, Maria Ines
; Rodríguez Fermepin, Martin
; Fernandez, Belisario Enrique
Fecha de publicación:
05/2015
Editorial:
Baishideng Publishing Group
Revista:
World Journal of Nephrology
ISSN:
2220-6124
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Fluid homeostasis, blood pressure and redox balance in the kidney are regulated by an intricate interaction between local and systemic anti-natriuretic and natriuretic systems. Intrarenal dopamine plays a central role on this interactive network. By activating specific receptors, dopamine promotes sodium excretion and stimulates anti-oxidant and anti-inflammatory pathways. Different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome, hypertension and renal inflammation, can be associated with impaired action of renal dopamine including alteration in biosynthesis, dopamine receptor expression and signal transduction. Given its properties on the regulation of renal blood flow and sodium excretion, exogenous dopamine has been postulated as a potential therapeutic strategy to prevent renal failure in critically ill patients. The aim of this review is to update and discuss on the most recent findings about renal dopaminergic system and its role in several diseases involving the kidneys and the potential use of dopamine as a nephroprotective agent.
Palabras clave:
Dopamine
,
Hypertension
,
Sodium Excretion
,
Oxidative Stress
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Identificadores
Colecciones
Articulos(ININCA)
Articulos de INST.DE INVEST.CARDIOLOGICAS (I)
Articulos de INST.DE INVEST.CARDIOLOGICAS (I)
Citación
Choi, Marcelo Roberto; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Kravetz, Maria Cecilia; Roson, Maria Ines; et al.; Renal dopaminergic system: pathophysiological implications and clinical perspectives; Baishideng Publishing Group; World Journal of Nephrology; 4; 2; 5-2015; 196-212
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