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dc.contributor.author
Geninatti Crich, S.
dc.contributor.author
Cadenazzi, M.
dc.contributor.author
Lanzardo, S.
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Conti, L.
dc.contributor.author
Ruiu, R.
dc.contributor.author
Alberti, D.
dc.contributor.author
Cavallo, F.
dc.contributor.author
Cutrin, Juan Carlos
dc.contributor.author
Aime, S.
dc.date.available
2016-10-31T20:04:16Z
dc.date.issued
2015-03
dc.identifier.citation
Geninatti Crich, S.; Cadenazzi, M.; Lanzardo, S.; Conti, L.; Ruiu, R.; et al.; Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells; Taylor & Francis; Nanoscale And Microscale Thermophysical Engineering; 7; 15; 3-2015; 6527-6533
dc.identifier.issn
1556-7265
dc.identifier.uri
http://hdl.handle.net/11336/7875
dc.description.abstract
In this work the selective uptake of native horse spleen ferritin and apoferritin loaded with MRI contrast agents has been assessed in human breast cancer cells (MCF-7 and MDA-MB-231). The higher expression of L-ferritin receptors (SCARA5) led to an enhanced uptake in MCF-7 as shown in T2 and T1 weighted MR images, respectively. The high efficiency of ferritin internalization in MCF-7 has been exploited for the simultaneous delivery of curcumin, a natural therapeutic molecule endowed with antineoplastic and anti-inflammatory action, and the MRI contrast agent Gd-HPDO3A. This theranostic system is able to treat selectively breast cancer cells over-expressing ferritin receptors. By entrapping in apoferritin both Gd-HPDO3A and curcumin, it was possible to deliver a therapeutic dose of 167 μg ml−1 (as calculated by MRI) of this natural drug to MCF-7 cells, thus obtaining a significant reduction of cell proliferation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ferritin
dc.subject
Theranostic
dc.subject
Breast Cancer
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Mri
dc.subject.classification
Otras Nanotecnología
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-30T17:11:51Z
dc.journal.volume
7
dc.journal.number
15
dc.journal.pagination
6527-6533
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Londres
dc.description.fil
Fil: Geninatti Crich, S.. Universitã â Di Torino; Italia
dc.description.fil
Fil: Cadenazzi, M.. Universitã â Di Torino; Italia
dc.description.fil
Fil: Lanzardo, S.. Universitã â Di Torino; Italia
dc.description.fil
Fil: Conti, L.. Universitã â Di Torino; Italia
dc.description.fil
Fil: Ruiu, R.. Universitã â Di Torino; Italia
dc.description.fil
Fil: Alberti, D.. Universitã â Di Torino; Italia
dc.description.fil
Fil: Cavallo, F.. Universitã â Di Torino; Italia
dc.description.fil
Fil: Cutrin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Università  Di Torino; Italia
dc.description.fil
Fil: Aime, S.. Universitã â Di Torino; Italia
dc.journal.title
Nanoscale And Microscale Thermophysical Engineering
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR00352K#!divAbstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/C5NR00352K
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