Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Are changes in the wnt/b-catenin pathway involved in cocaine and stress-induced long-term neuroadaptations?

Cuesta, SantiagoIcon ; Pacchioni, Alejandra MariaIcon
Fecha de publicación: 10/2017
Editorial: Elyns Publishing group
Revista: Journal of Addiction and Preventive Medicine
ISSN: 2474-5049
e-ISSN: 2474-5049
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Salud Ocupacional

Resumen

Drug addiction has been defined as a chronic relapsing brain disease, characterized by compulsive drug seeking and use, despite harmful consequences. This phenomenon has been extensively studied and the use of animal models has contributed to elucidate neurobiological bases of the different stages in the addiction process. For the past years, we have been studying the role of the Wnt (Wingless-related integration site) pathways in cocaine-induce neuroadaptations by using the behavioral sensitization paradigm to model addiction-like behaviors. The Wnt pathways are critical during the development of both the central and peripheral nervous systems. In particular, we centered our attention on the Wnt/β-catenin or canonical pathway. This pathway mediates the stabilization and nuclear translocation of the final effector β-catenin, where it can promote the expression of different target genes. Our findings reveal a specific spatiotemporal participation of the Wnt/β-catenin pathway in cocaine-induced behavioral sensitization. We found that while the initiation or development of sensitization involves an inhibition in the Prefrontal Cortex?s canonical pathway, the expression is related with activation in the Nucleus Accumbens. Furthermore, we recently discover that stress during adolescence has an impact on cocaine-induced effect in adulthood. Intriguingly, we also found that the exposure to this early life stress influence the activity of the Wnt/β-catenin pathway, proposing that this signaling pathway could be mediating the proactive effect of stress on drug properties. In this manuscript, we cover different mechanisms that may underlie cocaine- and stress-induced changes in the Wnt canonical pathway. We also revise the idea of this pathway as a common target for adolescent stress and for the vulnerability to drug abuse later in life. We suggest that the canonical Wnt pathway constitutes a promising target that may open a door to new therapeutic strategies for the treatment of cocaine addiction.
Palabras clave: Wnt Canonical Pathway , Sensitization , Prefrontal Cortex , Nucleus Accumbens
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 2.025Mb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/78755
URL: https://www.elynspublishing.com/journal/article/are-changes-in-the-wnt-catenin-p
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Cuesta, Santiago; Pacchioni, Alejandra Maria; Are changes in the wnt/b-catenin pathway involved in cocaine and stress-induced long-term neuroadaptations?; Elyns Publishing group; Journal of Addiction and Preventive Medicine; 2; 2; 10-2017; 1-8
Compartir
Estadísticas
Visualizaciones: 138
Descargas: 55

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • Sound Cloud

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

Ministerio
https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES