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dc.contributor.author
Guerri Guttenberg, Roberto Andrés
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dc.contributor.author
Castilla, Rocío
dc.contributor.author
Francos, Gabriela C.
dc.contributor.author
Muller, Angelica del Carmen
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dc.contributor.author
Ambrosio, Giuseppe
dc.contributor.author
Milei, Jose
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dc.date.available
2016-10-31T20:02:13Z
dc.date.issued
2013-02
dc.identifier.citation
Guerri Guttenberg, Roberto Andrés; Castilla, Rocío; Francos, Gabriela C.; Muller, Angelica del Carmen; Ambrosio, Giuseppe; et al.; Transforming Growth Factor b1 and Coronary Intimal Hyperplasia in Pediatric Patients With Congenital Heart Disease; Pulsus Group Inc; Canadian Journal Of Cardiology; 29; 7; 2-2013; 849-857
dc.identifier.issn
0828-282X
dc.identifier.uri
http://hdl.handle.net/11336/7873
dc.description.abstract
Background
Congenital heart defects or the process of their repair leads to an increased risk for adult cardiovascular disease compared with the general population. Intimal hyperplasia is a preatherosclerotic lesion that may be produced as a consequence of transforming growth factor β1 (TGF-β1) pathway activation. We studied the presence of intimal hyperplasia in arteries from a pediatric population with congenital heart disease (CHD) and TGF-β1 expression to enlighten its possible role in the genesis of these lesions.
Methods
Coronary arteries from 10 controls and 98 CHD patients (54% cyanotic type, 32% surgically repaired) were stained, and the presence and degree of intimal thickening were analyzed. The expression of TGF-β1 was studied by immunohistochemistry.
Results
The difference between the presence of coronary intimal hyperplasia in patients with cyanotic (35; 66.1%) and noncyanotic CHD (29; 64.3%) was not significant. However, surgically repaired CHD presented a higher rate of coronary intimal hyperplasia (80%) than did the group without surgical intervention (47.3%), P = 0.0002. The immunostaining for TGF-β1 analyzed in samples of patients with cyanotic and noncyanotic CHD showed no significant differences. However, TGF-β1 expression was more intense on the intimal layer of patients with surgically repaired CHD than on that of those without surgery (intimal area positive for TGF-β1, 50.43% vs 15.91%, respectively; Mann-Whitney U test P = 0.0005).
Conclusion
The high incidence of intimal hyperplasia in patients with surgically repaired CHD is correlated with TGF-β1 expression and may contribute to the development of atherosclerotic coronary artery disease in CHD patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pulsus Group Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Intimal Thickening
dc.subject
Tgf-ß1
dc.subject
Congenital Heart Disease
dc.subject.classification
Sistemas Cardíaco y Cardiovascular
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Transforming Growth Factor b1 and Coronary Intimal Hyperplasia in Pediatric Patients With Congenital Heart Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-30T17:09:17Z
dc.journal.volume
29
dc.journal.number
7
dc.journal.pagination
849-857
dc.journal.pais
Canadá
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dc.journal.ciudad
Ontario
dc.description.fil
Fil: Guerri Guttenberg, Roberto Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Castilla, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Francos, Gabriela C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina
dc.description.fil
Fil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Ambrosio, Giuseppe. Universita Di Perugia; Italia
dc.description.fil
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.journal.title
Canadian Journal Of Cardiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.cjca.2012.11.018
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0828282X12014730
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