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dc.contributor.author
Avila, Marco Fidel
dc.contributor.author
Cabezas, Ricardo
dc.contributor.author
Torrente, Daniel
dc.contributor.author
Gonzalez, Janneth
dc.contributor.author
Morales, Ludis
dc.contributor.author
Alvarez, Lisandro
dc.contributor.author
Capani, Francisco
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dc.contributor.author
Barreto, George E.
dc.date.available
2016-10-28T22:27:34Z
dc.date.issued
2013-06
dc.identifier.citation
Avila, Marco Fidel; Cabezas, Ricardo; Torrente, Daniel; Gonzalez, Janneth; Morales, Ludis; et al.; Novel interactions of GRP78: UPR and estrogen responses in the brain; Wiley; Cell Biology International; 37; 6; 6-2013; 522-532
dc.identifier.issn
1065-6995
dc.identifier.uri
http://hdl.handle.net/11336/7871
dc.description.abstract
Glucose-regulated protein 78 (GRP78; 78 kDa) belongs to a group of highly conserved heat shock proteins (Hsp) with important functions at the cellular level. The emerging interest for GRP78 relies on its different functions, both in normal and pathological circumstances. GRP78 regulates intracellular calcium, protein shaping, endoplasmic reticulum (ER) stress and cell survival by an immediate response to insults, and that its expression may also be regulated by estrogens. Although these roles are well explored, the mechanisms by which GRP78 induces these changes are not completely understood. In this review, we highlight various aspects related to the GRP78 functioning in cellular protection and repair in response to ER stress and unfolded protein response by the regulation of intracellular Ca2+ and other mechanisms. In this respect, the novel interactions between GRP78 and estrogens, such as estradiol and others, are analyzed in the context of the central nervous system (CNS). We also discuss the importance of GRP78 and estrogens in brain diseases including ischemia, Alzheimer's and Huntington's disorders. Finally, the main protective mechanisms of GRP78 and estrogens during ER dysfunction in the brain are described, and the prospective roles of GRP78 in therapeutic processes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Calcium
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Estrogens
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Grp78
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Neuroprotection
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Novel interactions of GRP78: UPR and estrogen responses in the brain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-30T17:09:12Z
dc.journal.volume
37
dc.journal.number
6
dc.journal.pagination
522-532
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlín
dc.description.fil
Fil: Avila, Marco Fidel. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: Cabezas, Ricardo. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: Torrente, Daniel. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: Gonzalez, Janneth. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: Morales, Ludis. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: Alvarez, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Barreto, George E.. Pontificia Universidad Javeriana; Colombia
dc.journal.title
Cell Biology International
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cbin.10058/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cbin.10058
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