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dc.contributor.author
Sydes, Daniel
dc.contributor.author
Kler, Pablo Alejandro
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Zipfl, P.
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Lutz, D.
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Bouwes, Hans
dc.contributor.author
Huhn, Carolin
dc.date.available
2019-06-21T02:29:05Z
dc.date.issued
2017-03
dc.identifier.citation
Sydes, Daniel; Kler, Pablo Alejandro; Zipfl, P.; Lutz, D.; Bouwes, Hans; et al.; On-chip intermediate potential measurements for the control of O electromigration in multi-channel networks in case of time-dependent potential changes.; Elsevier Science Sa; Sensors and Actuators B: Chemical; 240; 3-2017; 330-337
dc.identifier.issn
0925-4005
dc.identifier.uri
http://hdl.handle.net/11336/78626
dc.description.abstract
One of the greatest challenges in multi-channel networks for electromigrative separation techniques is the control of the leakage of sample constituents and band broadening at the channel intersections in microfluidic devices or capillary-chip interfaces, which can be achieved using fixed bias or pullback potentials. These may be implemented as the first separation dimension in a 2D setup, where the electric potential at the interface to the second dimension changes with time. Thus, a dynamic control via on-line potential measurement in combination with a feedback system is needed to control electromigration into the side channels. We here present for the first time a prototype for in-channel potential measurements using a low working current in combination with a Si3N4 passivated Ti/Pt electrode at the intersection of the channels in a microfluidic interface. Exemplarily we chose capillary electrophoresis and isotachophoresis as model applications with constant vs. dynamic potential. Parallel on-chip intersection potential measurements were successfully conducted without disturbing capillary zone electrophoretic and isotachophoretic analysis regarding separation and peak performance of amino acids chosen as model analytes. This was possible due to a Si3N4 passivation layer, but also due to an ad-hoc developed high impedance instrumentation, resulting in a very low measuring electric current. Simulations of the detected isotachophoretic cross-section potential allowed a deeper understanding of the potential development during the separation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Sa
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Capacitively Coupled Contactless Conductivity Detection
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Capillary Electrophoresis
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Dynamic Electric Potential Control
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Glass Microfluidic Interface
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Isotachophoresis
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Ingeniería de Sistemas y Comunicaciones
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Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
On-chip intermediate potential measurements for the control of O electromigration in multi-channel networks in case of time-dependent potential changes.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-19T16:54:45Z
dc.journal.volume
240
dc.journal.pagination
330-337
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Sydes, Daniel. Iptc - Karls Eberhardt Universität Tübingen; Alemania
dc.description.fil
Fil: Kler, Pablo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina
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Fil: Zipfl, P.. Fachhochschule Aalen; Alemania
dc.description.fil
Fil: Lutz, D.. Fachhochschule Aalen; Alemania
dc.description.fil
Fil: Bouwes, Hans. Ix-factory Gmbh; Alemania
dc.description.fil
Fil: Huhn, Carolin. Iptc - Karls Eberhardt Universität Tübingen; Alemania
dc.journal.title
Sensors and Actuators B: Chemical
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.snb.2016.08.152
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