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dc.contributor.author
Klie, Sebastian
dc.contributor.author
Osorio, Sonia
dc.contributor.author
Tohge, Takayuki
dc.contributor.author
Drincovich, Maria Fabiana
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dc.contributor.author
Fait, Aaron
dc.contributor.author
Giovannoni, Federico
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dc.contributor.author
Fernie, Alisdair R.
dc.contributor.author
Nikoloski, Zoran
dc.date.available
2016-10-27T21:10:08Z
dc.date.issued
2013-11
dc.identifier.citation
Klie, Sebastian; Osorio, Sonia; Tohge, Takayuki; Drincovich, Maria Fabiana; Fait, Aaron; et al.; Conserved changes in dynamics of metabolic processes during fruit development and ripening across species; American Society Of Plant Biologist; Plant Physiology.; 164; 1; 11-2013; 1-16
dc.identifier.issn
0032-0889
dc.identifier.uri
http://hdl.handle.net/11336/7829
dc.description.abstract
Computational analyses of molecular phenotypes traditionally aim at identifying biochemical components that exhibit differential expression under various scenarios (e.g. environmental and internal perturbations) in a single species. High-throughput metabolomics technologies allow the quantification of (relative) metabolite levels across developmental stages in different tissues, organs, and species. Novel methods for analyzing the resulting multiple data tables could reveal preserved dynamics of metabolic processes across species. The problem we address in this study is 2-fold. (1) We derive a single data table, referred to as a compromise, which captures information common to the investigated set of multiple tables containing data on different fruit development and ripening stages in three climacteric (i.e. peach [Prunus persica] and two tomato [Solanum lycopersicum] cultivars, Ailsa Craig and M82) and two nonclimacteric (i.e. strawberry [Fragaria × ananassa] and pepper [Capsicum chilense]) fruits; in addition, we demonstrate the power of the method to discern similarities and differences between multiple tables by analyzing publicly available metabolomics data from three tomato ripening mutants together with two tomato cultivars. (2) We identify the conserved dynamics of metabolic processes, reflected in the data profiles of the corresponding metabolites that contribute most to the determined compromise. Our analysis is based on an extension to principal component analysis, called STATIS, in combination with pathway overenrichment analysis. Based on publicly available metabolic profiles for the investigated species, we demonstrate that STATIS can be used to identify the metabolic processes whose behavior is similarly affected during fruit development and ripening. These findings ultimately provide insights into the pathways that are essential during fruit development and ripening across species.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society Of Plant Biologist
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Metabolomics Time-Series Data
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Fruit Development And Ripening
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Compromise of Data Tables
dc.subject
Multi-Way Data Analysis
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Conserved changes in dynamics of metabolic processes during fruit development and ripening across species
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-14T12:49:02Z
dc.journal.volume
164
dc.journal.number
1
dc.journal.pagination
1-16
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Rockville
dc.description.fil
Fil: Klie, Sebastian. Max Planck Institute of Molecular Plant Physiology; Alemania
dc.description.fil
Fil: Osorio, Sonia. Consejo Superior de Investigaciones Cientificas. Instituto de Hortofruticultura Subtropical y Mediterránea; España
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Fil: Tohge, Takayuki. Max Planck Institute of Molecular Plant Physiology; Alemania
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Fil: Drincovich, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
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Fil: Fait, Aaron. Ben-Gurion University of the Negrev; Israel
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Fil: Giovannoni, Federico. Cornell University; Estados Unidos
dc.description.fil
Fil: Fernie, Alisdair R.. Max Planck Institute of Molecular Plant Physiology; Alemania
dc.description.fil
Fil: Nikoloski, Zoran. Max Planck Institute of Molecular Plant Physiology; Alemania
dc.journal.title
Plant Physiology.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.plantphysiol.org/content/164/1/55.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875825/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1104/pp.113.226142
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