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Artículo

Beneficial lactobacilli: Effects on the vaginal tract in a murine experimental model

de Gregorio, Priscilla RominaIcon ; Juárez Tomás, María SilvinaIcon ; Santos, Viviana; Nader, Maria Elena FatimaIcon
Fecha de publicación: 11/2012
Editorial: Springer
Revista: Antonie van Leeuwenhoek
ISSN: 0003-6072
e-ISSN: 1572-9699
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Biotecnologías de la Salud

Resumen

Vaginal probiotics containing lactic acid bacteria with activity towards pathogenic microorganisms that cause urogenital tract infections have been proposed as a valid strategy for their prophylaxis and therapy. A murine experimental model was set up to evaluate the colonization capability of beneficial human lactobacilli and their effects on the mouse vaginal mucosa and innate immune cells. Five Lactobacillus strains were intravaginally inoculated into previously estrogenized BALB/c mice. The significance of the effects observed in the vaginal tract was determined by analysis of variance using the general linear model. The numbers of viable vaginal lactobacilli were significantly higher at proestrous-estrous than those at the metaestrous-diestrous phase and decreased markedly on the days after inoculation. Lactobacilli inoculation did not cause cytological or histological modifications of the murine vaginal tract. Moreover, the intravaginal administration of Lactobacillus salivarius CRL (Centro de Referencia para Lactobacilos culture collection) 1328 and Lactobacillus gasseri CRL 1263 did not affect the amounts of granulocytes and macrophages present in vaginal washings. In conclusion, the results demonstrate that vaginal lactobacilli did not produce adverse effects on the murine vaginal tract. Therefore, they could be proposed as safe probiotic candidates to promote a balanced microbiota in the urogenital tract.
Palabras clave: Lactobacillus Vaginal Colonization , Mouse Experimental Model , Urogenital Probiotic Candidates , Vaginal Innate Immune Cells
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/78283
DOI: http://dx.doi.org/10.1007/s10482-012-9752-9
URL: http://link.springer.com/article/10.1007%2Fs10482-012-9752-9
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Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
de Gregorio, Priscilla Romina; Juárez Tomás, María Silvina; Santos, Viviana; Nader, Maria Elena Fatima; Beneficial lactobacilli: Effects on the vaginal tract in a murine experimental model; Springer; Antonie van Leeuwenhoek; 102; 4; 11-2012; 569-580
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