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dc.contributor.author
Vicco, Miguel Hernán  
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Rodeles Antonelli, Luz María  
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Capovilla, Gabriela Soledad  
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Perrig, Melina Soledad  
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Choque, Ana Gabriela Herrera  
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Marcipar, Iván Sergio  
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Bottasso, Oscar Adelmo  
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Rodriguez, Celeste  
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Cuña, Washington  
dc.date.available
2019-06-13T20:21:58Z  
dc.date.issued
2016-10  
dc.identifier.citation
Vicco, Miguel Hernán; Rodeles Antonelli, Luz María; Capovilla, Gabriela Soledad; Perrig, Melina Soledad; Choque, Ana Gabriela Herrera; et al.; IgG Autoantibodies Induced by T. cruzi During Pregnancy: Correlation with Gravidity Complications and Early Outcome Assessment of the Newborns; Springer New York LLC; Maternal and Child Health Journal; 20; 10; 10-2016; 2057-2064  
dc.identifier.issn
1092-7875  
dc.identifier.uri
http://hdl.handle.net/11336/78280  
dc.description.abstract
Objective: The aim of the present research was to evaluate the correlation of vertically transmitted IgG antibodies induced by T. cruzi and newborn early outcome assessment, mainly birth weight and gestational age. Methods: We performed a cross-sectional study with 183 pregnant women (64 with asymptomatic Chagas disease) and their newborns. Both were subjected to complete clinical examination. Peripheral parasitemia was assessed in mother and neonates by parasite detection through microscopic examination of the buffycoat from mother’s peripheral and cord blood. Antibodies induced by T. cruzi, such as anti-FRA, anti-B13, anti-p2β and anti-T. cruzi were assessed by immunoassay. Birth weight, general condition evaluation by APGAR Score and gestational age by Capurro Score, were determined in newborns. Results: The rate of stillbirth background and pregnancy-induced hypertension were higher in patients with Chagas disease (p = 0.01 and p = 0.02, respectively). Parasitemia was detectable in 17 mothers and 4 newborns. The newborns of mothers with detectable parasitemia presented decreased gestational age (p = 0.006) and body weight (p = 0.04). Mostly all the mothers with Chagas disease and all their newborns have positive values of antibodies induced by T. cruzi; however, only anti-p2β showed to be related to the presence of complication during pregnancy (OR 2.35, p = 0.036), and to low birth weight (OR 1.55, p = 0.02). Conclusions: Low birth weight and decreased postnatal estimation of maturity were related to detectable parasitemia in the mother. Also, vertical transmission of T. cruzi-induced autoantibodies might have clinical implication in newborns given the negative association between anti-p2β values and weight.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer New York LLC  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Anti-P2β  
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Antibodies  
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Chagas Disease  
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Low Birth Weight  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
IgG Autoantibodies Induced by T. cruzi During Pregnancy: Correlation with Gravidity Complications and Early Outcome Assessment of the Newborns  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-05-27T19:34:38Z  
dc.identifier.eissn
1573-6628  
dc.journal.volume
20  
dc.journal.number
10  
dc.journal.pagination
2057-2064  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Vicco, Miguel Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Tecnología Inmunológica; Argentina  
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Fil: Rodeles Antonelli, Luz María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Tecnología Inmunológica; Argentina  
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Fil: Capovilla, Gabriela Soledad. Universidad Nacional del Litoral; Argentina  
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Fil: Perrig, Melina Soledad. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Tecnología Inmunológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina  
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Fil: Choque, Ana Gabriela Herrera. Universidad Mayor de San Andrés; Bolivia  
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Fil: Marcipar, Iván Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Tecnología Inmunológica; Argentina  
dc.description.fil
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
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Fil: Rodriguez, Celeste. Universidad Mayor de San Andrés; Bolivia  
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Fil: Cuña, Washington. Universidad Mayor de San Andrés; Bolivia  
dc.journal.title
Maternal and Child Health Journal  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10995-016-2035-8  
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info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10995-016-2035-8