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dc.contributor.author
Caceres Guido, Paulo Arturo
dc.contributor.author
Travaglianti, Mónica
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Castro, Graciela
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Licciardone, Nieves
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Ferreyra, Oscar
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Bramuglia, Guillermo Federico
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García Bournissen, Facundo
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Schaiquevich, Paula Susana
dc.date.available
2019-06-13T18:48:30Z
dc.date.issued
2017-03
dc.identifier.citation
Caceres Guido, Paulo Arturo; Travaglianti, Mónica; Castro, Graciela; Licciardone, Nieves; Ferreyra, Oscar; et al.; Population pharmacokinetics of amikacin in neonatal intensive care unit patients; Australasian Medical Journal Pty Ltd; Australasian Medical Journal; 10; 2; 3-2017; 140-144
dc.identifier.issn
1836-1935
dc.identifier.uri
http://hdl.handle.net/11336/78246
dc.description.abstract
Background Amikacin treatment requires close monitoring of blood concentrations to increase the probability that levels achieved are both effective and safe. Aims We described population pharmacokinetics parameters of amikacin in newborns from a Neonatal Intensive Care Unit with suspected or documented sepsis. Methods A nonlinear mixed-effect model approach was used to analyse the data. Results Twenty seven neonates were enrolled. Final parameter estimates were: Ke(h-1)=0.232x(CR) Exp-0.85; V(mL/kg)=497. Conclusion Weight and serum creatinine are associated with neonatal amikacin volume of distribution and elimination constant rate, respectively. The presence of sepsis may decrease amikacin elimination, although this observation should be further explored. These results could help to individualize amikacin dosage for neonates.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Australasian Medical Journal Pty Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Amikacin
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Neonates
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Population Pharmacokinetics
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Population pharmacokinetics of amikacin in neonatal intensive care unit patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-04T14:41:41Z
dc.journal.volume
10
dc.journal.number
2
dc.journal.pagination
140-144
dc.journal.pais
Australia
dc.description.fil
Fil: Caceres Guido, Paulo Arturo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Travaglianti, Mónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Castro, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Licciardone, Nieves. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Ferreyra, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
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Fil: Bramuglia, Guillermo Federico. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
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Fil: García Bournissen, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
dc.description.fil
Fil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.journal.title
Australasian Medical Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.21767/AMJ.2017.2833
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://amj.net.au/index.php/AMJ/article/view/2833
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