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dc.contributor.author
Morande, Pablo Elías
dc.contributor.author
Borge, Mercedes
dc.contributor.author
Abreu, Cecilia
dc.contributor.author
Galletti, Jeremías Gastón
dc.contributor.author
Zanetti, Samanta Romina
dc.contributor.author
Nannini, Paula Romina
dc.contributor.author
Bezares, Fernando Raimundo
dc.contributor.author
Pantano, Sergio
dc.contributor.author
Dighiero, Guillermo
dc.contributor.author
Oppezzo, Pablo
dc.contributor.author
Gamberale, Romina
dc.contributor.author
Giordano, Mirta Nilda
dc.date.available
2016-10-26T21:25:07Z
dc.date.issued
2015-01
dc.identifier.citation
Morande, Pablo Elías; Borge, Mercedes; Abreu, Cecilia; Galletti, Jeremías Gastón; Zanetti, Samanta Romina; et al.; Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi; Taylor & Francis; Leukemia And Lymphoma; 56; 4; 1-2015; 1-8
dc.identifier.issn
1042-8194
dc.identifier.uri
http://hdl.handle.net/11336/7811
dc.description.abstract
Chronic lymphocytic leukemia (CLL) is the main cause of autoimmune hemolytic anemia (AHA). However, the cellular basis underlying this strong association remains unclear. We previously demonstrated that leukemic B cells from patients with CLL recognize the erythrocyte protein Band 3, a prevalent autoantigen in AHA. Here we show that the major binding site of Band 3 on leukemic cells is an extrinsic protein identified as high-mobility group nucleosome binding protein 2 (HMGN2), a nucleosome-interacting factor which has not been previously reported at the cell surface. T lymphocytes do not express HMGN2 or bind Band 3. Removal of HMGN2 from the cell membrane abrogated the capacity of Band 3-pulsed CLL cells to induce CD4 + T cell proliferation. We conclude that surface HMGN2 in leukemic B cells is involved in Band 3 binding, uptake and presentation to CD4 + T lymphocytes, and as such may favor the initiation of AHA secondary to CLL.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Autoimmune Hemolytic Anemia
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Chronic Lymphocytic Leukemia
dc.subject
Hmgn2
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-02-22T14:08:13Z
dc.journal.volume
56
dc.journal.number
4
dc.journal.pagination
1-8
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Abreu, Cecilia. Instituto Pasteur de Montevideo. Unidad de Biologia Molecular; Uruguay
dc.description.fil
Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Zanetti, Samanta Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Nannini, Paula Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Bezares, Fernando Raimundo. Hospital Teodoro Alvarez; Argentina
dc.description.fil
Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: Dighiero, Guillermo. Hospital Maciel; Uruguay
dc.description.fil
Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo. Unidad de Biologia Molecular; Uruguay
dc.description.fil
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
dc.journal.title
Leukemia And Lymphoma
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10428194.2014.957205
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10428194.2014.957205


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