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dc.contributor.author
Morande, Pablo Elías  
dc.contributor.author
Borge, Mercedes  
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Abreu, Cecilia  
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Galletti, Jeremías Gastón  
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Zanetti, Samanta Romina  
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Nannini, Paula Romina  
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Bezares, Fernando Raimundo  
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Pantano, Sergio  
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Dighiero, Guillermo  
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Oppezzo, Pablo  
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Gamberale, Romina  
dc.contributor.author
Giordano, Mirta Nilda  
dc.date.available
2016-10-26T21:25:07Z  
dc.date.issued
2015-01  
dc.identifier.citation
Morande, Pablo Elías; Borge, Mercedes; Abreu, Cecilia; Galletti, Jeremías Gastón; Zanetti, Samanta Romina; et al.; Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi; Taylor & Francis; Leukemia And Lymphoma; 56; 4; 1-2015; 1-8  
dc.identifier.issn
1042-8194  
dc.identifier.uri
http://hdl.handle.net/11336/7811  
dc.description.abstract
Chronic lymphocytic leukemia (CLL) is the main cause of autoimmune hemolytic anemia (AHA). However, the cellular basis underlying this strong association remains unclear. We previously demonstrated that leukemic B cells from patients with CLL recognize the erythrocyte protein Band 3, a prevalent autoantigen in AHA. Here we show that the major binding site of Band 3 on leukemic cells is an extrinsic protein identified as high-mobility group nucleosome binding protein 2 (HMGN2), a nucleosome-interacting factor which has not been previously reported at the cell surface. T lymphocytes do not express HMGN2 or bind Band 3. Removal of HMGN2 from the cell membrane abrogated the capacity of Band 3-pulsed CLL cells to induce CD4 + T cell proliferation. We conclude that surface HMGN2 in leukemic B cells is involved in Band 3 binding, uptake and presentation to CD4 + T lymphocytes, and as such may favor the initiation of AHA secondary to CLL.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Autoimmune Hemolytic Anemia  
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Chronic Lymphocytic Leukemia  
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Hmgn2  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Surface localization of high-mobility group nucleosome-binding protein 2 (HMGN2) on leukemic B cells from chronic lymphocytic leukemia patients is related to secondary autoimmune hemolytic anemi  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-02-22T14:08:13Z  
dc.journal.volume
56  
dc.journal.number
4  
dc.journal.pagination
1-8  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina. Instituto Pasteur de Montevideo; Uruguay  
dc.description.fil
Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Abreu, Cecilia. Instituto Pasteur de Montevideo. Unidad de Biologia Molecular; Uruguay  
dc.description.fil
Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Zanetti, Samanta Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Nannini, Paula Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Bezares, Fernando Raimundo. Hospital Teodoro Alvarez; Argentina  
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Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay  
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Fil: Dighiero, Guillermo. Hospital Maciel; Uruguay  
dc.description.fil
Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo. Unidad de Biologia Molecular; Uruguay  
dc.description.fil
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina  
dc.journal.title
Leukemia And Lymphoma  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10428194.2014.957205  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10428194.2014.957205