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dc.contributor.author
Caterina, Maria Cristina
dc.contributor.author
Perillo, Isabel Amalia
dc.contributor.author
Villalonga, Ximena Soledad
dc.contributor.author
Amiano, Nicolás Oscar
dc.contributor.author
Payés, Cristian
dc.contributor.author
Sanchez, Mercedes Leonor
dc.contributor.author
Salerno, Alejandra
dc.date.available
2015-06-16T20:36:59Z
dc.date.issued
2013-12
dc.identifier.citation
Caterina, Maria Cristina; Perillo, Isabel Amalia; Villalonga, Ximena Soledad; Amiano, Nicolás Oscar; Payés, Cristian; et al.;New Green Synthesis and Antineoplastic Activity of bis (3-arylimidazolidinyl-1)methanes; SCIRP; Open Journal of Medicinal Chemistry; 3; 12-2013; 121-127
dc.identifier.issn
2164-3121
dc.identifier.uri
http://hdl.handle.net/11336/779
dc.description.abstract
A new green synthesis and anti-tumor activity of the series of bis (3-arylimidazolidinyl-1) methanes 1 - 6 are described. The compounds were synthesized from the corresponding N-arylethylenediamine and trioxane as source of formaldehyde and the reactions were performed in heterogeneous phase catalyzed by an acidic ion-exchange resin (Amberlyst 15). The compounds were tested with the Sulforhodamine B assay according to the protocol of the National Cancer Institute for several cell lines. The results were expressed as percentage inhibition of growth cell in comparison with the full growth of the cells without treatment. Cytotoxicity on normal cells using the Annexing-PI staining and flow cytometry has been evaluated. The parent compound, bis(3-phenylimidazolidinyl-1)methane 1 and the monohalogenated derivatives 4-chlorophenyl 3 and 3-bromophenyl 5 showed antineoplastic activity, 60%, 82% and 89% inhibition growth cell respectively on the human colon cell line (HCT116). The 4-tolyl derivative 6 presented inhibitory activity (73% inhibition of growth cell) on human lung adenocarcinoma cell line (A549) and 62% on human mammary cell line MCF-7.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SCIRP
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antineoplastics
dc.subject
Molecules
dc.subject
Bis (3-Arylimidazolidinyl-1) Methanes
dc.subject
Tumor Cell Lines
dc.subject.classification
Ciencias Médicas y de la Salud
dc.subject.classification
Biotecnología de la Salud
dc.subject.classification
Tecnologías Que Involucran la Identificación de Adn, Proteínas y Enzimas, y Cómo Influyen En El Conjunto de Enfermedades y Mantenimiento del Bienestar
dc.title
New Green Synthesis and Antineoplastic Activity of bis (3-arylimidazolidinyl-1)methanes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
3
dc.journal.pagination
121-127
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Caterina, Maria Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Quimica Orgánica; Argentina;
dc.description.fil
Fil: Perillo, Isabel Amalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Quimica Orgánica; Argentina;
dc.description.fil
Fil: Villalonga, Ximena Soledad. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Estudios Farmacologicos y Botánicos; Argentina;
dc.description.fil
Fil: Amiano, Nicolás Oscar. Universidad de Buenos Aires. Facultad de Medicina. Cat.de Farmacología; Argentina;
dc.description.fil
Fil: Payés, Cristian. Universidad de Buenos Aires. Facultad de Medicina. Cat.de Farmacología; Argentina;
dc.description.fil
Fil: Sanchez, Mercedes Leonor. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Estudios Farmacologicos y Botánicos; Argentina;
dc.description.fil
Fil: Salerno, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Química Orgánica;Argentina;
dc.journal.title
Open Journal of Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/ojmc.2013.34014
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/Journal/PaperInformation.aspx?paperID=40423#.VYCIp_mqqko
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/journal/PaperInformation.aspx?PaperID=40423
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