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dc.contributor.author
Zacho, Helle D.
dc.contributor.author
Biurrun Manresa, José Alberto
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dc.contributor.author
Aleksyniene, Ramune
dc.contributor.author
Ejlersen, June A.
dc.contributor.author
Fledelius, Joan
dc.contributor.author
Bertelsen, Henrik
dc.contributor.author
Petersen, Lars J.
dc.date.available
2019-06-11T16:42:37Z
dc.date.issued
2017-12
dc.identifier.citation
Zacho, Helle D.; Biurrun Manresa, José Alberto; Aleksyniene, Ramune; Ejlersen, June A.; Fledelius, Joan; et al.; Three-minute SPECT/CT is sufficient for the assessment of bone metastasis as add-on to planar bone scintigraphy: prospective head-to-head comparison to 11-min SPECT/CT; Springer Verlag; EJNMMI Research; 7; 1; 12-2017; 1-7
dc.identifier.issn
2191-219X
dc.identifier.uri
http://hdl.handle.net/11336/77946
dc.description.abstract
Background: The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as “add-on” to whole-body bone scintigraphy (WB-BS) for the investigation of bone metastases. Consecutive cancer patients referred for WB-BS who underwent SPECT/CT in addition to WB-BS were included. Std-SPECT, UF-SPECT, and low-dose CT were performed (std-SPECT: matrix 128 × 128, zoom factor 1, 20 s/view, 32 views; UF-SPECT: identical parameters except for 10 s/view and 16 views, reducing the acquisition time from 11 to 3 min). A consensus diagnosis was reached by two observers for each set of images (WB-BS + standard SPECT/CT or WB-BS + UF-SPECT/CT) using a three-category evaluation scale: M0: no bone metastases; M1: bone metastases; and Me: equivocal findings. Results: Among the 104 included patients, most presented with prostate cancer (n = 71) or breast cancer (n = 28). Using WB-BS + std-SPECT/CT, 71 (68%) patients were classified as M0, 19 (18%) as M1, and 14 (14%) as Me. Excellent agreement was observed between WB-BS + std-SPECT/CT and WB-BS + UF-SPECT/CT using the three-category scale: kappa = 0.91 (95% CI 0.84–0.97). No difference in observer agreement between cancer types was detected. SPECT/CT provided a definitive classification in 90 of 104 cases in which WB-BS was not entirely diagnostic. Conclusions: To investigate potential bone metastases, UF-SPECT/CT can be conducted as add-on to WB-BS to notably reduce the SPECT acquisition time without compromising diagnostic confidence.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Agreement
dc.subject
Bone Metastases
dc.subject
Bone Scintigraphy
dc.subject
Fast Acquisition
dc.subject
Spect/Ct
dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Three-minute SPECT/CT is sufficient for the assessment of bone metastasis as add-on to planar bone scintigraphy: prospective head-to-head comparison to 11-min SPECT/CT
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-10T14:44:41Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-7
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlín
dc.description.fil
Fil: Zacho, Helle D.. Aalborg University Hospital; Dinamarca
dc.description.fil
Fil: Biurrun Manresa, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Entre Ríos. Universidad Nacional de Entre Ríos. Centro de Investigaciones y Transferencia de Entre Ríos; Argentina. Aalborg University Hospital; Dinamarca
dc.description.fil
Fil: Aleksyniene, Ramune. Aalborg University Hospital; Dinamarca
dc.description.fil
Fil: Ejlersen, June A.. Regional Hospital West Jutland; Dinamarca
dc.description.fil
Fil: Fledelius, Joan. Regional Hospital West Jutland; Dinamarca
dc.description.fil
Fil: Bertelsen, Henrik. Aalborg University Hospital; Dinamarca
dc.description.fil
Fil: Petersen, Lars J.. Aalborg University Hospital; Dinamarca
dc.journal.title
EJNMMI Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1186/s13550-016-0252-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://ejnmmires.springeropen.com/articles/10.1186/s13550-016-0252-1
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