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dc.contributor.author
Mamone, Leandro Ariel
dc.contributor.author
Saenz, Daniel Alberto
dc.contributor.author
Vallecorsa, Pablo Daniel
dc.contributor.author
Batlle, Alcira Maria del C.
dc.contributor.author
Di Venosa, Gabriela Mariana
dc.contributor.author
Casas, Adriana Gabriela
dc.date.available
2016-10-24T20:04:39Z
dc.date.issued
2014-02
dc.identifier.citation
Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; et al.; Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy; Hindawi Publishing Corporation; International Journal Of Photoenergy; 2014; 2-2014; 1-8
dc.identifier.issn
1110-662X
dc.identifier.uri
http://hdl.handle.net/11336/7787
dc.description.abstract
Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Photodynamic Therapy
dc.subject
Photoprotection
dc.subject
Collaea Argentina
dc.subject
Argentinean Plants
dc.subject.classification
Oncología
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-30T17:10:43Z
dc.journal.volume
2014
dc.journal.pagination
1-8
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil
Fil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil
Fil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil
Fil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil
Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil
Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.journal.title
International Journal Of Photoenergy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijp/2014/436463/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2014/436463


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