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dc.contributor.author Mamone, Leandro Ariel
dc.contributor.author Saenz, Daniel Alberto
dc.contributor.author Vallecorsa, Pablo Daniel
dc.contributor.author Batlle, Alcira Maria del C.
dc.contributor.author Di Venosa, Gabriela Mariana
dc.contributor.author Casas, Adriana Gabriela
dc.date.available 2016-10-24T20:04:39Z
dc.date.issued 2014-02
dc.identifier.citation Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; et al.; Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy; Hindawi Publishing Corporation; International Journal Of Photoenergy; 2014; 2-2014; 1-8
dc.identifier.issn 1110-662X
dc.identifier.uri http://hdl.handle.net/11336/7787
dc.description.abstract Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.
dc.format application/pdf
dc.language.iso eng
dc.publisher Hindawi Publishing Corporation
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject PHOTODYNAMIC THERAPY
dc.subject PHOTOPROTECTION
dc.subject COLLAEA ARGENTINA
dc.subject ARGENTINEAN PLANTS
dc.subject.classification Oncología
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-08-30T17:10:43Z
dc.journal.volume 2014
dc.journal.pagination 1-8
dc.journal.pais Estados Unidos
dc.journal.ciudad New York
dc.description.fil Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil Fil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil Fil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil Fil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.description.fil Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
dc.journal.title International Journal Of Photoenergy
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijp/2014/436463/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2014/436463


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  • Articulos(CIPYP) [36]
    Articulos de CENTRO DE INVEST. SOBRE PORFIRINAS Y PORFIRIAS

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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)