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dc.contributor.author
Martinez, Maria del Carmen  
dc.contributor.author
Ruspini, Silvina Fernanda  
dc.contributor.author
Afonso, Susana Graciela  
dc.contributor.author
Meiss, Roberto  
dc.contributor.author
Buzaleh, Ana Maria  
dc.contributor.author
Batlle, Alcira Maria del C.  
dc.date.available
2016-10-24T19:59:01Z  
dc.date.issued
2015-01  
dc.identifier.citation
Martinez, Maria del Carmen; Ruspini, Silvina Fernanda; Afonso, Susana Graciela; Meiss, Roberto; Buzaleh, Ana Maria; et al.; Experimental Protoporphyria: Effect of bile acids on liver damage induced by griseofulvin; Hindawi Publishing Corporation; BioMed Research International; 2015; 1-2015; 1-10  
dc.identifier.issn
2314-6133  
dc.identifier.uri
http://hdl.handle.net/11336/7782  
dc.description.abstract
The effect of bile acids administration to an experimental mice model of Protoporphyria produced by griseofulvin (Gris) was investigated. The aim was to assess whether porphyrin excretion could be accelerated by bile acids treatment in an attempt to diminish liver damage induced by Gris. Liver damage markers, heme metabolism, and oxidative stress parameters were analyzed in mice treated with Gris and deoxycholic (DXA), dehydrocholic (DHA), chenodeoxycholic, or ursodeoxycholic (URSO). The administration of Gris alone increased the activities of glutathione reductase (GRed), superoxide dismutase (SOD), alkaline phosphatase (AP), gamma glutamyl transpeptidase (GGT), and glutathione-S-transferase (GST), as well as total porphyrins, glutathione (GSH), and cytochrome P450 (CYP) levels in liver. Among the bile acids studied, DXA and DHA increased PROTO IX excretion, DXA also abolished the action of Gris, reducing lipid peroxidation and hepatic GSH and CYP levels, and the activities of GGT, AP, SOD, and GST returned to control values. However, porphyrin accumulation was not prevented by URSO; instead this bile acid reduced ALA-S and the antioxidant defense enzymes system activities. In conclusion, we postulate that DXA acid would be more effective to prevent liver damage induced by Gris.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Hindawi Publishing Corporation  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
Bile Acids  
dc.subject
Eritropoyetic Protoporphyria  
dc.subject
Oxidative Stress  
dc.subject
Griseofulvine  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Experimental Protoporphyria: Effect of bile acids on liver damage induced by griseofulvin  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-08-30T17:12:24Z  
dc.journal.volume
2015  
dc.journal.pagination
1-10  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Martinez, Maria del Carmen. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina  
dc.description.fil
Fil: Ruspini, Silvina Fernanda. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina  
dc.description.fil
Fil: Afonso, Susana Graciela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina  
dc.description.fil
Fil: Meiss, Roberto. Academia Nacional de Medicina de Buenos Aires; Argentina  
dc.description.fil
Fil: Buzaleh, Ana Maria. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina  
dc.description.fil
Fil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina  
dc.journal.title
BioMed Research International  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2015/436319/  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2015/436319