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dc.contributor.author
Yannarelli, Gustavo Gabriel
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dc.contributor.author
Pacienza, Natalia Alejandra
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dc.contributor.author
Cuniberti, Luis Alberto
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dc.contributor.author
Medin, Jeffrey
dc.contributor.author
Davies, John
dc.contributor.author
Keating, Armand
dc.date.available
2019-06-07T17:41:43Z
dc.date.issued
2013-01
dc.identifier.citation
Yannarelli, Gustavo Gabriel; Pacienza, Natalia Alejandra; Cuniberti, Luis Alberto; Medin, Jeffrey; Davies, John; et al.; Brief report: The potential role of epigenetics on multipotent cell differentiation capacity of mesenchymal stromal cells; Alphamed Press; Stem Cells; 31; 1; 1-2013; 215-220
dc.identifier.issn
1066-5099
dc.identifier.uri
http://hdl.handle.net/11336/77772
dc.description.abstract
Human umbilical cord perivascular cells (HUCPVCs) are a readily available source of mesenchymal stromal cells (MSCs) for cell therapy. We were interested in understanding how differences from human bone marrow (BM)-derived MSCs might yield insights into MSC biology. We found that HUCPVCs exhibited increased telomerase activity and longer telomeres compared with BM-MSCs. We also observed enhanced expression of the pluripotency factors OCT4, SOX2, and NANOG in HUCPVCs. The methylation of OCT4 and NANOG promoters was similar in both cell types, indicating that differences in the expression of pluripotency factors between the MSCs were not associated with epigenetic changes. MSC methylation at these loci is greater than reported for embryonic stem cells but less than in dermal fibroblasts, suggesting that multipotentiality of MSCs is epigenetically restricted. These results are consistent with the notion that the MSC population (whether BM- or HUCPV-derived) exhibits higher proliferative capacity and contains more progenitor cells than do dermal fibroblasts. © AlphaMed Press.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Alphamed Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Epigenetics
dc.subject
Mesenchymal Stromal Cells
dc.subject
Pluripotency Factors
dc.subject
Telomerase
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Brief report: The potential role of epigenetics on multipotent cell differentiation capacity of mesenchymal stromal cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-07T14:29:46Z
dc.journal.volume
31
dc.journal.number
1
dc.journal.pagination
215-220
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Charlotte
dc.description.fil
Fil: Yannarelli, Gustavo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Princess Margaret Hospital; Canadá. Universidad Favaloro; Argentina
dc.description.fil
Fil: Pacienza, Natalia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University Health Network; Canadá. Universidad Favaloro; Argentina
dc.description.fil
Fil: Cuniberti, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
dc.description.fil
Fil: Medin, Jeffrey. University Health Network; Canadá
dc.description.fil
Fil: Davies, John. University of Toronto; Canadá
dc.description.fil
Fil: Keating, Armand. Princess Margaret Hospital; Canadá. University of Toronto; Canadá
dc.journal.title
Stem Cells
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/stem.1262
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1002/stem.1262
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