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dc.contributor.author
de Queiroz, Alvaro Antonio Alençar
dc.contributor.author
Gomes Ferraz, Humberto
dc.contributor.author
Abraham, Gustavo Abel
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dc.contributor.author
Fernández, María del Mar
dc.contributor.author
López Bravo, Antonio
dc.contributor.author
San Román, Julio
dc.date.available
2019-06-05T19:43:29Z
dc.date.issued
2003-01-04
dc.identifier.citation
de Queiroz, Alvaro Antonio Alençar; Gomes Ferraz, Humberto; Abraham, Gustavo Abel; Fernández, María del Mar; López Bravo, Antonio; et al.; Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 64A; 1; 4-1-2003; 147-154
dc.identifier.issn
1549-3296
dc.identifier.uri
http://hdl.handle.net/11336/77664
dc.description.abstract
Different poly(vinyl alcohol) (PVA)/chitosan lactate (ChL)‐blended hydrogels containing nitrofurazone as a local anti‐infective drug were prepared by the phase‐inversion technique. The swelling degree, surface free energy, mechanical properties, and nitrofurazone release of these membranes were determined. Blood compatibility of these systems was evaluated by the open‐static platelet adhesion test with whole human blood. The results showed that water absorption into the PVA/ChL membranes slowed down, governed by the rate at which the dressing interacted with the physiological fluid. Swelling degree values up to 200% were observed. The rate of release of nitrofurazone seemed to depend on the ChL percentage on the blend as well as the pH of the solution. The surface free energy values were in the range of 20–30 dynes/cm, which was appropriate for a favorable interaction with blood. From the Young's module curve, it could be seen that elastic hydrogels were obtained with increment of ChL in the PVA/ChL blends. Values of platelet adhesion and whole blood clotting times for the PVA/ChL blends as well as the increase of ChL, which appears to reduce the fibrinogen adsorption on the PVA/ChL membranes, demonstrated that the blood compatibility of PVP/ChL blends is superior to that separated polymers. The results of in vivo experiments in rats were in very good agreement with these observations, suggesting that PVA/ChL may serve as a new type of potential wound‐dressing material.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Poly(Vinyl Alcohol)
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Chitosan Lactate
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Hydrogel
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Blood Compatibility
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Wound Healing
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-15T16:45:06Z
dc.journal.volume
64A
dc.journal.number
1
dc.journal.pagination
147-154
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: de Queiroz, Alvaro Antonio Alençar. Universidade Federal de Itajuba; Brasil
dc.description.fil
Fil: Gomes Ferraz, Humberto. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Instituto en Ciencia y Tecnología de Polímeros; España. Consejo Superior de Investigaciones Científicas; España
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Fil: Fernández, María del Mar. Instituto en Ciencia y Tecnología de Polímeros; España. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: López Bravo, Antonio. Hospital Provincial de Ávila; España
dc.description.fil
Fil: San Román, Julio. Hospital Provincial de Ávila; España
dc.journal.title
Journal of Biomedical Materials Research Part A
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.10265
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jbm.a.10265
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