Artículo
Central Neural Tumor Destruction by Controlled Release of a Synthetic Glycoside Dispersed in a Biodegradable Polymeric Matrix
Fernández Mayoralas, Alfonso; de la Figuera, Natalia; Zurita, Mercedes; Vaquero, Jesús; Abraham, Gustavo Abel
; San Román, Julio; Nieto Sampedro, Manuel
Fecha de publicación:
18/04/2003
Editorial:
American Chemical Society
Revista:
Journal of Medicinal Chemistry
ISSN:
0022-2623
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
An octyl N-acetylglucosaminide derivative with a pentaerythritol chain at position 6 has been synthesized and evaluated as an inhibitor of neural tumor growth. The glycoside inhibited the growth of a neuroectodermic tumor implanted in rats and, when loaded on a slow-delivery polymer disk, caused the destruction of cultured human astroblastoma obtained after surgical biopsy.
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Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Citación
Fernández Mayoralas, Alfonso; de la Figuera, Natalia; Zurita, Mercedes; Vaquero, Jesús; Abraham, Gustavo Abel; et al.; Central Neural Tumor Destruction by Controlled Release of a Synthetic Glycoside Dispersed in a Biodegradable Polymeric Matrix; American Chemical Society; Journal of Medicinal Chemistry; 46; 8; 18-4-2003; 1286-1288
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