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dc.contributor.author
Abraham, Gustavo Abel
dc.contributor.author
Gallardo, Alberto
dc.contributor.author
San Roman, Julio
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Fernández Mayoralas, Alfonso
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Zurita, Mercedes
dc.contributor.author
Vaquero, Jesús
dc.date.available
2019-06-04T17:49:51Z
dc.date.issued
2003-03-07
dc.identifier.citation
Abraham, Gustavo Abel; Gallardo, Alberto; San Roman, Julio; Fernández Mayoralas, Alfonso; Zurita, Mercedes; et al.; Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 64A; 4; 7-3-2003; 638-647
dc.identifier.issn
1549-3296
dc.identifier.uri
http://hdl.handle.net/11336/77591
dc.description.abstract
Graft copolymers of poly(ϵ‐caprolactone) (PCL) on poly(dimethylacrylamide) (PDMAm), poly(methylmethacrylate) (PMMA), or on copolymers of poly(DMAm‐co‐MMA) have been synthesized and characterized by 1H NMR spectroscopy, differential scanning calorimetry (DSC), and size exclusion chromatography (SEC). These partially biodegradable copolymer matrices have been proposed as drug delivery systems for the release of low‐molecular‐weight glycosides. Octyl‐N‐acetyl‐6‐O‐[2,2‐bis(hydroxymethyl)‐3‐hydroxypropyl]‐α‐D‐glucosamide, a synthetic carbohydrate able to inhibit the proliferation of human malignant glioma cells in culture and transplanted glioma in rats was selected as drug model. The in vitro aqueous behavior of four drug‐loaded and unloaded graft copolymers of different MMA: DMAm and PCL ratios has been analyzed performing swelling, degradation, and drug release experiments. An intimate dependence of the aqueous behavior with the composition has been found. The higher was the DMAm content, the higher was the hydrophilicity of the synthesized systems as well as the swelling, degradation, and drug release rate. In vivo experiments in pigs demonstrated the very good tolerance of drug‐loaded implanted polymeric discs, and that >95% of the charged drug is released after 2 months' implantation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Partially Biodegradable Matrices
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Graft Copolymers
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Antitumoral Drugs
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Drug Release
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In Vivo Experiments
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Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Recubrimientos y Películas
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-15T16:45:10Z
dc.identifier.eissn
1552-4965
dc.journal.volume
64A
dc.journal.number
4
dc.journal.pagination
638-647
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
dc.description.fil
Fil: Gallardo, Alberto. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
dc.description.fil
Fil: San Roman, Julio. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
dc.description.fil
Fil: Fernández Mayoralas, Alfonso. Consejo Superior de Investigaciones Científicas; España. Instituto de Química Orgánica General; España
dc.description.fil
Fil: Zurita, Mercedes. Clínica Puerta de Hierro; España
dc.description.fil
Fil: Vaquero, Jesús. Clínica Puerta de Hierro; España
dc.journal.title
Journal of Biomedical Materials Research Part A
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.10297
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jbm.a.10297
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