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dc.contributor.author
Rey, Mariana
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dc.contributor.author
Coirini, Hector
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dc.date.available
2016-10-20T14:23:36Z
dc.date.issued
2015-02-17
dc.identifier.citation
Rey, Mariana; Coirini, Hector; Synthetic neurosteroids on brain protection; Neural Regeneration Research; Neural Regeneration Research; 10; 1; 17-2-2015; 17-21
dc.identifier.issn
1673-5374
dc.identifier.uri
http://hdl.handle.net/11336/7753
dc.description.abstract
Neurosteroids, like allopregnanolone and pregnanolone, are endogenous regulators of neuronal excitability. Inside the brain, they are highly selective and potent modulators of GABAA receptor activity. Their anticonvulsant, anesthetics and anxiolytic properties are useful for the treatments of several neurological and psychiatric disorders via reducing the risks of side effects obtained with the commercial drugs. The principal disadvantages of endogenous neurosteroids administration are their rapid metabolism and their low oral bioavailability. Synthetic steroids analogues with major stability or endogenous neurosteroids stimulation synthesis might constitute promising novel strategies for the treatment of several disorders. Numerous studies indicate that the 3α-hydroxyl configuration is the key for binding and activity, but modifications in the steroid nucleus may emphasize different pharmacophores. So far, several synthetic steroids have been developed with successful neurosteroid-like effects. In this work, we summarize the properties of various synthetic steroids probed in trials throughout the analysis of several neurosteroids-like actions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Neural Regeneration Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Allopregnanolone
dc.subject
Synthetic Steroids
dc.subject
Gabaa Receptor
dc.subject
Neuroprotection
dc.subject
Cerebral Cortex
dc.subject
Hippocampus
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Synthetic neurosteroids on brain protection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-10-07T20:15:58Z
dc.identifier.eissn
1673-5374
dc.journal.volume
10
dc.journal.number
1
dc.journal.pagination
17-21
dc.journal.pais
India
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dc.journal.ciudad
Mumbai
dc.description.fil
Fil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Neural Regeneration Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4103/1673-5374.150640
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/25788907
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=1;spage=17;epage=21;aulast=Rey
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357103/
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