Cyclooxygenase-2 in testes of infertile men: Evidence for the induction of prostaglandin synthesis by interleukin-1β

As we previously reported, testes of men suffering from hypospermatogenesis and germ cell arrest or Sertoli cell-only syndrome show a major increase in the number of macrophages expressing interleukin-1β (IL-1β) and abundant expression of cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the biosynthesis of prostaglandins (PGs), in Leydig cells. In the present study we report [1] a positive correlation between IL-1β levels and COX-2 expression in testes of infertile patients, [2] the induction of COX-2 by IL-1β in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore [3] evidence for an IL-1β-dependent induction of testicular inflammatory states.

Palabras clave: Cox2 , Prostaglandins , Interleukin 1beta , Testis

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/77475

URL: https://www.sciencedirect.com/science/article/pii/S0015028210000993

DOI: https://doi.org/10.1016/j.fertnstert.2010.01.039

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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Citación

Matzkin, Maria Eugenia; Mayerhofer, Artur; Rossi, Soledad Paola; Gonzalez, Betina; Gonzalez, Candela Rocio; et al.; Cyclooxygenase-2 in testes of infertile men: Evidence for the induction of prostaglandin synthesis by interleukin-1β; Elsevier Science Inc; Fertility and Sterility; 94; 5; 10-2010; 1933-1936

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