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dc.contributor.author
Bilotas, Mariela Andrea
dc.contributor.author
Meresman, Gabriela Fabiana
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Stella, Inés
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Sueldo, Carlos
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Barañao, Rosa Ines
dc.date.available
2019-05-31T18:02:18Z
dc.date.issued
2010-05
dc.identifier.citation
Bilotas, Mariela Andrea; Meresman, Gabriela Fabiana; Stella, Inés; Sueldo, Carlos; Barañao, Rosa Ines; Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis; Elsevier Science Inc; Fertility and Sterility; 93; 8; 5-2010; 2513-2518
dc.identifier.issn
0015-0282
dc.identifier.uri
http://hdl.handle.net/11336/77467
dc.description.abstract
Objective: To evaluate the effect of aromatase inhibitors on ectopic endometrial growth and on the release of proangiogenic and proinflammatory factors in peritoneal fluid (PF). Design: Prospective experimental study. Setting: Animal research and laboratory facility. Animal(s): Female Balb/c mice 2 months of age. Intervention(s): Mice had surgery performed to induce endometriosis-like lesions. Treatment with anastrozole or letrozole was started on either postoperative day 1 or 28 and continued for 4 weeks. Main Outcome Measure(s): Endometriotic lesions were counted and measured and aromatase expression, cell proliferation, and apoptosis were assessed. Vascular endothelial growth factor (VEGF) and prostaglandin E (PGE) levels were evaluated in the PF. Result(s): Endometriosis-like lesions express aromatase P-450. Treatment with either anastrozole or letrozole did not prevent lesion establishment; however, it significantly decreased the size of the endometriotic lesion. When treatment was initiated on postoperative day 1, letrozole and anastrozole decreased cell proliferation and increased apoptosis. When treatment was started on postoperative day 28, both aromatase inhibitors decreased cell proliferation, but only anastrozole augmented apoptosis levels. In addition, letrozole reduced VEGF and PGE levels in PF. Anastrozole diminished VEGF content but did not cause any significant change in PGE levels. Conclusion(s): These findings support the further investigation of aromatase inhibition as a treatment option for endometriosis. © 2010 American Society for Reproductive Medicine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aromatase Inhibitors
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Endometriosis
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Pge
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Vegf
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-14T15:52:28Z
dc.journal.volume
93
dc.journal.number
8
dc.journal.pagination
2513-2518
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Bilotas, Mariela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Stella, Inés. Hospital Israelita; Argentina
dc.description.fil
Fil: Sueldo, Carlos. Centro de Estudios en Ginecología y Reproducción; Argentina
dc.description.fil
Fil: Barañao, Rosa Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Fertility and Sterility
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.fertnstert.2009.08.058
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0015028209035973
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