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Artículo

Re-wiring regulatory cell networks in immunity by galectin-glycan interactions

Blidner, Ada GabrielaIcon ; Mendez Huergo, Santiago PatricioIcon ; Cagnoni, AlejandroIcon ; Rabinovich, Gabriel AdrianIcon
Fecha de publicación: 14/11/2015
Editorial: Elsevier Science
Revista: Febs Letters
ISSN: 0014-5793
e-ISSN: 1873-3468
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Programs that control immune cell homeostasis are orchestrated through the coordinated action of a number of regulatory cell populations, including regulatory T cells, regulatory B cells, myeloid-derived suppressor cells, alternatively-activated macrophages and tolerogenic dendritic cells. These regulatory cell populations can prevent harmful inflammation following completion of protective responses and thwart the development of autoimmune pathology. However, they also have a detrimental role in cancer by favoring escape from immune surveillance. One of the hallmarks of regulatory cells is their remarkable plasticity as they can be positively or negatively modulated by a plethora of cytokines, growth factors and co-stimulatory signals that tailor their differentiation, stability and survival. Here we focus on the emerging roles of galectins, a family of highly conserved glycan-binding proteins in regulating the fate and function of regulatory immune cell populations, both of lymphoid and myeloid origins. Given the broad distribution of circulating and tissue-specific galectins, understanding the relevance of lectin-glycan interactions in shaping regulatory cell compartments will contribute to the design of novel therapeutic strategies aimed at modulating their function in a broad range of immunological disorders.
Palabras clave: Galectin1 , Glycan , Immunomodulation , Regulatory T Cell , Immunosuppression
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/7740
DOI: http://dx.doi.org/10.1016/j.febslet.2015.08.037
URL: http://www.sciencedirect.com/science/article/pii/S0014579315008078
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Blidner, Ada Gabriela; Mendez Huergo, Santiago Patricio; Cagnoni, Alejandro; Rabinovich, Gabriel Adrian; Re-wiring regulatory cell networks in immunity by galectin-glycan interactions; Elsevier Science; Febs Letters; 589; 22; 14-11-2015; 3407-3418
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