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dc.contributor.author
Gonzalez, Candela Rocio
dc.contributor.author
Inserra, Pablo Ignacio Felipe
dc.contributor.author
Terradas, Claudio
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Ponzio, Roberto Oscar
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Puigdomenech, Elisa
dc.contributor.author
Levalle, Oscar
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Vitullo, Alfredo Daniel
dc.contributor.author
Calandra, Ricardo Saul
dc.contributor.author
Gonzalez de Calvar, Silvia Ines
dc.date.available
2016-10-19T18:24:41Z
dc.date.issued
2015-01-31
dc.identifier.citation
Gonzalez, Candela Rocio; Inserra, Pablo Ignacio Felipe; Terradas, Claudio; Ponzio, Roberto Oscar; Puigdomenech, Elisa; et al.; Altered expression of aromatase, estrogen receptors and progesterone receptors in human leydig cell hyperplasia; Scientific Research; Advances in Bioscience and Biotechnology; 6; 1; 31-1-2015; 1-10
dc.identifier.issn
2156-8456
dc.identifier.uri
http://hdl.handle.net/11336/7738
dc.description.abstract
Testicular function is regulated by pituitary hormones and also by paracrine and autocrine factors. A number of reports have pointed out the importance of estrogens and progesterone in male reproductive tract. Recently, we have reported in testicular biopsies from men with Sertoli Cell Only Syndrome (SCO) or Hypospermatogenesis (H) with Leydig cell hyperplasia (LCH) an increase in the expression of the TGFB1 and its receptors ALK1 and endoglin, which are involved in the proliferation of Leydig cells. The aim of the present work was to analyze the expression of aromatase, estrogen and progesterone receptors (ERs, PR) in pathological testicular biopsies with SCO or H with and without LCH. The ERs and CYP19 proteins were detected in the Leydig cells from all pathological biopsies analyzed. Biopsies with SCO or H with LCH showed an increment in the immunostaining of CYP19 and ERs in the Leydig cells respect to biopsies without LCH. The gene expression of CYP19 was increased in SCO or H biopsies with LCH respect to SCO and H biopsies without LCH. PR was localized in Leydig cells and showed a significant increment in biopsies with LCH respect from biopsies without LCH. The gene expression of both PRA and PRB was increased in biopsies with LCH respect to biopsies without LCH. In concussion, alterations in the gene expression of aromatase, ERs, and PR and the likely interactions of these systems with locally produced factors such as growth factors and cytokines, might lead to Leydig cell proliferation in testicular pathology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Scientific Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Aromatase
dc.subject
Estrogen
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Progesterone
dc.subject
Leydig
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Altered expression of aromatase, estrogen receptors and progesterone receptors in human leydig cell hyperplasia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-10-07T20:16:03Z
dc.journal.volume
6
dc.journal.number
1
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Gonzalez, Candela Rocio. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y de Diagnóstico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Inserra, Pablo Ignacio Felipe. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y de Diagnóstico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Terradas, Claudio. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
dc.description.fil
Fil: Ponzio, Roberto Oscar. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Puigdomenech, Elisa. No especifíca;
dc.description.fil
Fil: Levalle, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Carlos G. Durand"; Argentina
dc.description.fil
Fil: Vitullo, Alfredo Daniel. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y de Diagnóstico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Gonzalez de Calvar, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Advances in Bioscience and Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/abb.2015.61001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53101
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