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Artículo

GH/STAT5 signaling during the growth period in livers of mice overexpressing GH

Martinez, Carolina SoledadIcon ; Piazza, Verónica GabrielaIcon ; Díaz, María EugeniaIcon ; Boparal, Raavnet K.; Arum, Oge; Ramirez, Maria CeciliaIcon ; Gonzalez, LorenaIcon ; Becu, DamasiaIcon ; Bartke, Andrzej; Turyn, DanielIcon ; Miquet, Johanna GabrielaIcon ; Sotelo, Ana IsabelIcon
Fecha de publicación: 04/2015
Editorial: Bioscientifica
Revista: Journal Of Molecular Endocrinology
ISSN: 0952-5041
e-ISSN: 1479-6813
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

GH/STAT5 signaling is desensitized in the liver in adult transgenic mice overexpressing GH; however, these animals present greater body size. To assess whether the STAT5 pathway is active during the growth period in the liver in these animals, and how signaling modulators participate in this process, growing transgenic mice and normal siblings were evaluated. STAT5 does not respond to an acute GH-stimulus, but displays higher basal phosphorylation in the livers of growing GH-overexpressing mice. GH receptor and the positive modulators glucocorticoid receptor and HNF1 display greater abundance in transgenic animals, supporting the activity of STAT5. The negative modulators cytokine-induced suppressor and PTP1B are increased in GH-overexpressing mice. The suppressors SOCS2 and SOCS3 exhibit higher mRNA levels in transgenic mice but lower protein content, indicating that they are being actively degraded. Therefore, STAT5 signaling is increased in the liver in GH-transgenic mice during the growth period, with a balance between positive and negative effectors resulting in accelerated but controlled growth.
Palabras clave: Growth Hormone , Liver , Stat5 , Development , Signal Transduction
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/7736
DOI: http://dx.doi.org/10.1530/JME-14-0262
URL: http://jme.endocrinology-journals.org/content/54/2/171.long
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811361/
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Martinez, Carolina Soledad; Piazza, Verónica Gabriela; Díaz, María Eugenia; Boparal, Raavnet K.; Arum, Oge; et al.; GH/STAT5 signaling during the growth period in livers of mice overexpressing GH; Bioscientifica; Journal Of Molecular Endocrinology; 54; 2; 4-2015; 171-184
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