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dc.contributor.author
Osterman, Andreas
dc.contributor.author
Stellberger, Thorsten
dc.contributor.author
Gebhardt, Anna
dc.contributor.author
Kurz, M.arisa
dc.contributor.author
Friedel, Caroline C.
dc.contributor.author
Uetz, Peter
dc.contributor.author
Nitschko, Hans
dc.contributor.author
Baiker, Armin
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dc.contributor.author
Vizoso Pinto, María Guadalupe
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dc.date.available
2019-05-24T19:21:23Z
dc.date.issued
2015-10
dc.identifier.citation
Osterman, Andreas; Stellberger, Thorsten; Gebhardt, Anna; Kurz, M.arisa; Friedel, Caroline C.; et al.; The Hepatitis E virus intraviral interactome; Nature Publishing Group; Scientific Reports; 5; 13872; 10-2015; 1-13
dc.identifier.uri
http://hdl.handle.net/11336/77084
dc.description.abstract
Hepatitis E Virus (HEV) is an emerging virus causing epidemic acute hepatitis in developing countries as well as sporadic cases in industrialized countries. The life cycle of HEV is still poorly understood and the lack of efficient cell culture systems and animal models are the principal limitations for a detailed study of the viral replication cycle. Here we exhaustively examine all possible intraviral protein-protein interactions (PPIs) of HEV by systematic Yeast two-hybrid (Y2H) and LuMPIS screens, providing a basis for studying the function of these proteins in the viral replication cycle. Key PPIs correlate with the already published HEV 3D structure. Furthermore, we report 20 novel PPIs including the homodimerization of the RNA dependent RNA polymerase (RdRp), the self-interaction of the papain like protease, and ORF3 interactions with the papain-like protease and putative replicase components: RdRp, methylase and helicase. Furthermore, we determined the dissociation constant (Kd) of ORF3 interactions with the viral helicase, papain-like protease and methylase, which suggest a regulatory function for ORF3 in orchestrating the formation of the replicase complex. These interactions may represent new targets for antiviral drugs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Y2h
dc.subject
Protein Interactions
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Lumpis
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Thermophoresis
dc.subject
Viral Cycle
dc.subject
Hepatitis e Virus
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The Hepatitis E virus intraviral interactome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-23T13:18:50Z
dc.identifier.eissn
2045-2322
dc.journal.volume
5
dc.journal.number
13872
dc.journal.pagination
1-13
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Osterman, Andreas. Ludwig Maximilians Universitat. Max Von Pettenkofer Institute; Alemania
dc.description.fil
Fil: Stellberger, Thorsten. Bavarian Health And Food Safety Authority (lgl); Alemania
dc.description.fil
Fil: Gebhardt, Anna. Ludwig Maximilians Universitat. Max Von Pettenkofer Institute; Alemania
dc.description.fil
Fil: Kurz, M.arisa. Ludwig Maximilians Universitat. Max Von Pettenkofer Institute; Alemania
dc.description.fil
Fil: Friedel, Caroline C.. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Uetz, Peter. Center For The Study Of Biological Complexity, Vcu, Usa; Estados Unidos
dc.description.fil
Fil: Nitschko, Hans. Ludwig Maximilians Universitat. Max Von Pettenkofer Institute; Alemania
dc.description.fil
Fil: Baiker, Armin. Bavarian Health And Food Safety Authority (lgl); Alemania
dc.description.fil
Fil: Vizoso Pinto, María Guadalupe. Ludwig Maximilians Universitat. Max Von Pettenkofer Institute; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep13872
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038/srep13872
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