Artículo
DNp63 Is regulated by BMP4 signaling and Is required for early epidermal development in Xenopus
Tríbulo, Celeste
; Barrionuevo, María Guadalupe del Valle
; Agüero, Tristán Horacio
; Sanchez, Sara Serafina del V.
; Calcaterra, Nora Beatriz
; Aybar, Manuel Javier
Fecha de publicación:
11/2012
Editorial:
Wiley-liss, Div John Wiley & Sons Inc
Revista:
Developmental Dynamics
ISSN:
1058-8388
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
It has been established in several models that the p63 gene has an important role in the development of the epidermis and its derivatives. In Xenopus, only the DNp63 isoform of this gene has been cloned and its role during epidermal development remains unknown. In this work, we showed that DNp63 is expressed in the non-neural ectoderm since the gastrula stage and that it is regulated by the bone morphogenetic protein 4 (BMP4) signaling pathway. Our in vivo and in vitro experiments demonstrated that DNp63 is required in the earliest inductive steps of epidermal development. The overexpression of DNp63 caused an increase in epidermal markers with a suppression of neural induction while the blocking of DNp63 led to the opposite results. Finally, we found that DNp63 acts as an anti-apoptotic gene, regulating the transcription of some apoptotic and anti-apoptotic factors. Taken together, these results suggest that DNp63 is an essential gene in early epidermal specification under the control of BMP4.
Palabras clave:
Epidermis
,
Specification
,
Bmp4
,
Apoptosis
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Identificadores
Colecciones
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Tríbulo, Celeste; Barrionuevo, María Guadalupe del Valle; Agüero, Tristán Horacio; Sanchez, Sara Serafina del V.; Calcaterra, Nora Beatriz; et al.; DNp63 Is regulated by BMP4 signaling and Is required for early epidermal development in Xenopus; Wiley-liss, Div John Wiley & Sons Inc; Developmental Dynamics; 241; 2; 11-2012; 257-269
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