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dc.contributor.author
Blois, Sandra M.
dc.contributor.author
Freitag, Nancy
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dc.contributor.author
Tirado-González, Irene
dc.contributor.author
Cheng, Shi-Bin
dc.contributor.author
Heimesaat, Markus M.
dc.contributor.author
Bereswill, Stefan
dc.contributor.author
Rose, Matthias
dc.contributor.author
Conrad, Melanie L.
dc.contributor.author
Barrientos, Gabriela Laura
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dc.contributor.author
Sharma, Surendra
dc.date.available
2019-05-23T20:00:45Z
dc.date.issued
2017-12
dc.identifier.citation
Blois, Sandra M.; Freitag, Nancy; Tirado-González, Irene; Cheng, Shi-Bin; Heimesaat, Markus M.; et al.; NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017; 1-9
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/76977
dc.description.abstract
DC-NK cell interactions are thought to influence the development of maternal tolerance and de novo angiogenesis during early gestation. However, it is unclear which mechanism ensures the cooperative dialogue between DC and NK cells at the feto-maternal interface. In this article, we show that uterine NK cells are the key source of IL-10 that is required to regulate DC phenotype and pregnancy success. Upon in vivo expansion of DC during early gestation, NK cells expressed increased levels of IL-10. Exogenous administration of IL-10 was sufficient to overcome early pregnancy failure in dams treated to achieve simultaneous DC expansion and NK cell depletion. Remarkably, DC expansion in IL-10-/- dams provoked pregnancy loss, which could be abrogated by the adoptive transfer of IL-10+/+ NK cells and not by IL-10-/- NK cells. Furthermore, the IL-10 expressing NK cells markedly enhanced angiogenic responses and placental development in DC expanded IL-10-/- dams. Thus, the capacity of NK cells to secrete IL-10 plays a unique role facilitating the DC-NK cell dialogue during the establishment of a healthy gestation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Infertility
dc.subject
Reproductive Disorders
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-23T14:00:32Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-9
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Blois, Sandra M.. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Freitag, Nancy. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Tirado-González, Irene. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Cheng, Shi-Bin. University Brown; Estados Unidos
dc.description.fil
Fil: Heimesaat, Markus M.. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Bereswill, Stefan. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Rose, Matthias. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Conrad, Melanie L.. Charité – Universitätsmedizin Berlin;
dc.description.fil
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán; Argentina
dc.description.fil
Fil: Sharma, Surendra. University Brown; Estados Unidos
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038/s41598-017-02333-8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-02333-8
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