Artículo
17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins
Jerez S, Sierra L y Peral de Bruno M.; Jerez, Susana Josefina
; Sierra, Liliana Beatríz; Peral de Bruno, María
Fecha de publicación:
01/2012
Editorial:
Elsevier Science Inc
Revista:
Prostaglandins
ISSN:
1098-8823
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The present study investigated the role of CYP-enzymes in the modulation of vasoconstrictor responses to angiotensin II in rabbit aortae. In arteries with the endothelium-intact (E+) the CYP-inhibitor, 17-octadecynoic acid (17 ODYA), increased the efficacy to angiotensin II (17-ODYA-effect) as well as simultaneous incubation with miconazole (epoxygenase-inhibitor) and CAY 10434 (ω-hydroxylase-inhibitor). The removal of endothelium (E−) caused potentiation of the 17 ODYA-effect. Therefore, endothelium-dependent and -independent mechanisms would be involved. 17-ODYA and miconazole reduced Ach-relaxation. Indomethacin blocked the 17-ODYA-effect in E+ and E− arteries but blunted the response to angiotensin II only in E+ arteries. NS 398 (cyclooxygenase-2-inhibitor) blocked the 17-ODYA-effect and reduced angiotensin II affinity as well as SQ 29548 (thromboxane-prostanoid (TP) receptor-inhibitor). In E− arteries, CAY 10434 enhanced angiotensin II response as well as 17-ODYA. SC 560 (cyclooxygenase-1-inhibitor) and NS 398 partially blocked the 17-ODYA-effect. In conclusion, 17-ODYA induced endothelial dysfunction by inhibiting CYP-epoxygenase and thus improves vasoconstrictor cyclooxygenase-2 metabolites release acting through TP receptors. The endothelium-independent mechanism of 17-ODYA-effect may involve increase of vasoconstrictor cyclooxygenase-metabolites induced by prostaglandin-ω-hydroxylase-inhibition.
Palabras clave:
Angiotensin Ii
,
Vascular Response
,
17-Octadecynoic
,
Cyclooxygenase
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Jerez S, Sierra L y Peral de Bruno M.; Jerez, Susana Josefina; Sierra, Liliana Beatríz; Peral de Bruno, María; 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins; Elsevier Science Inc; Prostaglandins; 97; 1-2012; 36-42
Compartir
Altmétricas