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dc.contributor.author
Saccheri, María C.
dc.contributor.author
Cianciulli, Tomás F.
dc.contributor.author
Lax, Jorge A.
dc.contributor.author
Gagliargi, Juan A.
dc.contributor.author
Caceres, Guillermo L.
dc.contributor.author
Quarin, Alejandra E.
dc.contributor.author
Kisinovsky, Issac
dc.contributor.author
Rozenfeld, Paula Adriana
dc.contributor.author
Reisin, Ricardo C.
dc.date.available
2019-05-21T22:25:19Z
dc.date.issued
2013-10-19
dc.identifier.citation
Saccheri, María C.; Cianciulli, Tomás F.; Lax, Jorge A.; Gagliargi, Juan A.; Caceres, Guillermo L.; et al.; Two-Dimensional Speckle Tracking Echocardiography for Early Detection of Myocardial Damage in Young Patients with Fabry Disease; Wiley Blackwell Publishing, Inc; Echocardiography (mount Kisco, N.y.); 30; 9; 19-10-2013; 1069-1077
dc.identifier.issn
0742-2822
dc.identifier.uri
http://hdl.handle.net/11336/76830
dc.description.abstract
Fabry disease (FD) is characterized by left ventricular hypertrophy (LVH). Conventional echocardiography is not sensitive enough to perform the preclinical diagnosis To assess whether longitudinal myocardial strain of the left ventricle (LV), using speckle tracking, is useful to detect early myocardial involvement in FD. Forty‐four patients with FD who were diagnosed with genetic testing were prospectively included and were compared to a sex‐matched control group. They were divided into three groups: 22 with LVH (Group I), 22 without LVH (Group II), and 22 healthy volunteers (Group III). LV longitudinal strain was measured from the apical views. An ANOVA test was used for multiple comparisons for variables with a normal distribution, and a Kruskal–Wallis test was used for variables with non‐Gaussian distribution. Longitudinal LV strain was different in the three groups: it was ≥−15% in at least one segment in all Group I patients, in 50% of patients of Group II and in no patient of Group III. Seventy percent of the segments with abnormal strain in Group II were located in the basal regions (32/46). These findings show that the presence of at least one strain value ≥−15% demonstrates subclinical myocardial dysfunction in patients with preclinical FD. Longitudinal myocardial LV strain measured with speckle tracking is a useful tool to detect early myocardial involvement in young patients with FD. This information allows the detection and treatment of myocardial dysfunction at an early stage, which is of high clinical importance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Echocardiography
dc.subject
Fabry Disease
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Two-Dimensional Speckle Tracking Echocardiography for Early Detection of Myocardial Damage in Young Patients with Fabry Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-14T18:13:00Z
dc.journal.volume
30
dc.journal.number
9
dc.journal.pagination
1069-1077
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Saccheri, María C.. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina
dc.description.fil
Fil: Cianciulli, Tomás F.. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina
dc.description.fil
Fil: Lax, Jorge A.. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina
dc.description.fil
Fil: Gagliargi, Juan A.. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina
dc.description.fil
Fil: Caceres, Guillermo L.. Centro para la Enfermedad de Fabry; Argentina
dc.description.fil
Fil: Quarin, Alejandra E.. Centro para la Enfermedad de Fabry; Argentina
dc.description.fil
Fil: Kisinovsky, Issac. Centro para la Enfermedad de Fabry; Argentina
dc.description.fil
Fil: Rozenfeld, Paula Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina
dc.description.fil
Fil: Reisin, Ricardo C.. Hospital Británico de Buenos Aires; Argentina
dc.journal.title
Echocardiography (mount Kisco, N.y.)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/echo.12216
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/echo.12216
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