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dc.contributor.author
Seja, Patricia
dc.contributor.author
Schonewille, Martijn
dc.contributor.author
Spitzmaul, Guillermo Federico
dc.contributor.author
Badura, Aleksandra
dc.contributor.author
Klein, Ilse
dc.contributor.author
Rudhard, York
dc.contributor.author
Wisden, William
dc.contributor.author
Hübner, Christian A
dc.contributor.author
De Zeeuw, Chris I
dc.contributor.author
Jentsch, Thomas J
dc.date.available
2019-05-17T20:35:51Z
dc.date.issued
2012-03-17
dc.identifier.citation
Seja, Patricia; Schonewille, Martijn; Spitzmaul, Guillermo Federico; Badura, Aleksandra; Klein, Ilse; et al.; Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo-ocular learning; Embo; Embo Journal; 31; 5; 17-3-2012; 1217-1230
dc.identifier.issn
0261-4189
dc.identifier.uri
http://hdl.handle.net/11336/76674
dc.description.abstract
Cerebellar cortical throughput involved in motor control comprises granule cells (GCs) and Purkinje cells (PCs), both of which receive inhibitory GABAergic input from interneurons. The GABAergic input to PCs is essential for learning and consolidation of the vestibulo-ocular reflex, but the role of GC excitability remains unclear. We now disrupted the Kcc2 K-Cl cotransporter specifically in either cell type to manipulate their excitability and inhibition by GABA A-receptor Cl - channels. Although Kcc2 may have a morphogenic role in synapse development, Kcc2 disruption neither changed synapse density nor spine morphology. In both GCs and PCs, disruption of Kcc2, but not Kcc3, increased [Cl -] i roughly two-fold. The reduced Cl - gradient nearly abolished GABA-induced hyperpolarization in PCs, but in GCs it merely affected excitability by membrane depolarization. Ablation of Kcc2 from GCs impaired consolidation of long-term phase learning of the vestibulo-ocular reflex, whereas baseline performance, short-term gain-decrease learning and gain consolidation remained intact. These functions, however, were affected by disruption of Kcc2 in PCs. GC excitability plays a previously unknown, but specific role in consolidation of phase learning.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Embo
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dendritic Spine
dc.subject
Gaba Switch
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Glycine Receptor
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Potassium-Chloride Cotransporter
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Synaptic Inhibition
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo-ocular learning
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-14T21:34:32Z
dc.identifier.eissn
1460-2075
dc.journal.volume
31
dc.journal.number
5
dc.journal.pagination
1217-1230
dc.journal.pais
Alemania
dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Seja, Patricia. Leibniz-Institut für Molekulare Pharmakologie; Alemania. Max-Delbruck-Centrum für Molekulare Medizin; Alemania
dc.description.fil
Fil: Schonewille, Martijn. Erasmus MC; Países Bajos
dc.description.fil
Fil: Spitzmaul, Guillermo Federico. Leibniz-Institut für Molekulare Pharmakologie; Alemania. Max-Delbruck-Centrum für Molekulare Medizin; Alemania
dc.description.fil
Fil: Badura, Aleksandra. Erasmus MC; Países Bajos
dc.description.fil
Fil: Klein, Ilse. Universitat Hamburg; Alemania
dc.description.fil
Fil: Rudhard, York. Universitat Hamburg; Alemania
dc.description.fil
Fil: Wisden, William. Imperial College London; Reino Unido
dc.description.fil
Fil: Hübner, Christian A. Universitat Hamburg; Alemania. Universitat Jena; Alemania
dc.description.fil
Fil: De Zeeuw, Chris I. Erasmus MC; Países Bajos. Charite-Universitatsmedizin Berlin; Alemania
dc.description.fil
Fil: Jentsch, Thomas J. Leibniz-Institut für Molekulare Pharmakologie; Alemania. Universitat Hamburg; Alemania. Charite-Universitatsmedizin Berlin; Alemania
dc.journal.title
Embo Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://emboj.embopress.org/content/31/5/1217
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/emboj.2011.488
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