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dc.contributor.author
Pérez Akly, Manuel
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Schiava, Marianela
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Melcom, Mario
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Rodríguez, Gabriel
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Gargiulo Monachelli, Gisella Mariana
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Bettini, Mariela
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Reisin, Ricardo
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Bendersky, Mariana
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Barroso, Fabio
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Brand, Patricio
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de Ambrosi, Bruno
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Di Egidio, Marianna
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Fiorotto, Luis
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Jáuregui, Agustín
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Landriscina, Paula
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Marchesoni, Cintia
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Mazia, Claudio
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Rey, Roberto
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Rugiero, Marcelo
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Salutto, Valeria Luján
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Tillard, Belén
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Fulgenzi, Ernesto
dc.date.available
2019-05-15T22:22:27Z
dc.date.issued
2017-10
dc.identifier.citation
Pérez Akly, Manuel; Schiava, Marianela; Melcom, Mario; Rodríguez, Gabriel; Gargiulo Monachelli, Gisella Mariana; et al.; Estudio epidemiolgico multicentrico sobre esclerosis lateral amiotrofica en la Ciudad de Buenos Aires; Sociedad Neurológica Argentina; Neurología Argentina; 9; 4; 10-2017; 225-230
dc.identifier.issn
1853-0028
dc.identifier.uri
http://hdl.handle.net/11336/76516
dc.description.abstract
Introduction: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of unknown cause, characterized by the simultaneous involvement of the upper and lower motor neurons. Epidemiological studies have estimated its annual incidence between 0.31 and 3.2 and its prevalence between 0.8 and 8.5 cases per 100,000 inhabitants. The epidemiological information in our country is limited to specialized centers. The present study presents the results of an epidemiological study in ELA performed in the Autonomous City of Buenos Aires (CABA).
Methods: A multicentric retrospective study was conducted. Patients with defined and probable ALS according to the El Escorial Criteria, evaluated between January 1, 2012 and December 31, 2013, who lived in the CABA at the onset of symptoms, were included. The calculation of the incidence was based on the 2010 census.
Results: We included 103 patients (55 men), with a mean age of 64 years. The onset of symptoms was in the lower limbs at 39%, upper extremities at 25% and bulbar at 26%. The initial symptom was weakness in 58% and dysarthria in 20%; 9% had dementia associated with ALS. The mean time to diagnosis was 14.5 months. Thirty new cases/patients were diagnosed between 01/06/2012 and 01/06/2013, with an incidence rate of 1.04 per 100,000 inhabitants.
Conclusions: The epidemiological characteristics of ALS in CABA are similar to those reported in the universal literature. Further studies are needed to determine if these findings are applicable to the rest of the Argentine population.
dc.description.abstract
Introduction: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of unknown cause, characterized by the simultaneous involvement of the upper and lower motor neurons. Epidemiological studies have estimated its annual incidence between 0.31 and 3.2 and its prevalence between 0.8 and 8.5 cases per 100,000 inhabitants. The epidemiological information in our country is limited to specialized centers. The present study presents the results of an epidemiological study in ELA performed in the Autonomous City of Buenos Aires (CABA).
Methods: A multicentric retrospective study was conducted. Patients with defined and probable ALS according to the El Escorial Criteria, evaluated between January 1, 2012 and December 31, 2013, who lived in the CABA at the onset of symptoms, were included. The calculation of the incidence was based on the 2010 census.
Results: We included 103 patients (55 men), with a mean age of 64 years. The onset of symptoms was in the lower limbs at 39%, upper extremities at 25% and bulbar at 26%. The initial symptom was weakness in 58% and dysarthria in 20%; 9% had dementia associated with ALS. The mean time to diagnosis was 14.5 months. Thirty new cases/patients were diagnosed between 01/06/2012 and 01/06/2013, with an incidence rate of 1.04 per 100,000 inhabitants.
Conclusions: The epidemiological characteristics of ALS in CABA are similar to those reported in the universal literature. Further studies are needed to determine if these findings are applicable to the rest of the Argentine population.
dc.format
application/pdf
dc.language.iso
spa
dc.publisher
Sociedad Neurológica Argentina
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Esclerosis Lateral Amiotrófica
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Epidemiología
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Ciudad de Buenos Aires
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Estudio Multicéntrico
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Estudio epidemiolgico multicentrico sobre esclerosis lateral amiotrofica en la Ciudad de Buenos Aires
dc.title
Multicentric epidemiological study in amyotrophic lateral sclerosis in the Autonomous City of Buenos Aires
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-04-25T14:11:33Z
dc.journal.volume
9
dc.journal.number
4
dc.journal.pagination
225-230
dc.journal.pais
España
dc.description.fil
Fil: Pérez Akly, Manuel. Sociedad Neurológica; Argentina
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Fil: Schiava, Marianela. Unidad Asistencial Doctor César Milstein; Argentina
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Fil: Melcom, Mario. Fundación para la Investigación en Neuroepidemiología; Argentina
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Fil: Rodríguez, Gabriel. Sociedad Neurológica; Argentina
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Fil: Gargiulo Monachelli, Gisella Mariana. Sociedad Neurológica; Argentina
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Fil: Bettini, Mariela. Sociedad Neurológica; Argentina
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Fil: Reisin, Ricardo. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Bendersky, Mariana. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Barroso, Fabio. Sociedad Neurológica; Argentina
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Fil: Brand, Patricio. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina
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Fil: de Ambrosi, Bruno. Sociedad Neurológica; Argentina
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Fil: Di Egidio, Marianna. Sociedad Neurológica; Argentina
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Fil: Fiorotto, Luis. Sociedad Neurológica; Argentina
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Fil: Jáuregui, Agustín. Sociedad Neurológica; Argentina
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Fil: Landriscina, Paula. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Marchesoni, Cintia. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Mazia, Claudio. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Rey, Roberto. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Rugiero, Marcelo. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Salutto, Valeria Luján. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Tillard, Belén. Sociedad Neurológica; Argentina
dc.description.fil
Fil: Fulgenzi, Ernesto. Sociedad Neurológica; Argentina
dc.journal.title
Neurología Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S185300281730068X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuarg.2017.07.004
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