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Artículo

Advances in development of a contraceptive vaccine against human chorionic gonadotropin

Talwar, Gursaran P.; Gupta, Jagdish C.; Rulli, Susana BeatrizIcon ; Sharma, Radhey S.; Nand, Kripa N.; Bandivdekar, Atmaram H.; Atrey, Nishu; Singh, Priyanka
Fecha de publicación: 08/2015
Editorial: Informa Healthcare
Revista: Expert Opinion on Biological Therapy
ISSN: 1471-2598
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Introduction: There is continuing need for contraceptives. According to World Health Organization, 210 million pregnancies occur each year, out of which some 80 million are unintended. A vaccine offering privacy and periodic intake would be an attractive proposition.Areas covered: The article is a brief review of three vaccines developed against human chorionic gonadotropin (hCG) with progressively better attributes. Clinical trials have proven in more than one country the complete safety and reversibility of the anti-hCG vaccine(s) in women. Vaccination does not entail any disturbance in levels of reproductive tract hormones of the woman or any disturbance in menstrual regularity and bleeding profiles. Phase II clinical trials show the effective prevention of pregnancy in sexually active women of proven fertility. A recombinant vaccine amenable to industrial production has been developed; it induces substantially higher antibody titers in mice of four different genetic strains than those required to prevent pregnancy in women. Rigorous toxicology studies have been completed on this vaccine in rodents and marmosets.Expert opinion: This unique vaccine, requiring periodic intake and demonstrating no impairment of ovulation, hormonal profiles and menstrual regularity, is on the verge of final clinical trials under the aegis of the Indian Council of Medical Research and should be a valuable addition to the available contraceptives.
Palabras clave: Contraception , Fertility Control , Human Chorionic Gonadotropin
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/76410
DOI: https://dx.doi.org/10.1517/14712598.2015.1049943
URL: https://www.tandfonline.com/doi/full/10.1517/14712598.2015.1049943
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Talwar, Gursaran P.; Gupta, Jagdish C.; Rulli, Susana Beatriz; Sharma, Radhey S.; Nand, Kripa N.; et al.; Advances in development of a contraceptive vaccine against human chorionic gonadotropin; Informa Healthcare; Expert Opinion on Biological Therapy; 15; 8; 8-2015; 1183-1190
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