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dc.contributor.author
Gibon, Julien  
dc.contributor.author
Unsain, Nicolas  
dc.contributor.author
Gamache, Karine  
dc.contributor.author
Thomas, Rhalena A.  
dc.contributor.author
De Leon, Andres  
dc.contributor.author
Johnstone, Aaron  
dc.contributor.author
Nader, Karim  
dc.contributor.author
Séguéla, Philippe  
dc.contributor.author
Barker, Philip A.  
dc.date.available
2019-05-14T17:54:50Z  
dc.date.issued
2016-09  
dc.identifier.citation
Gibon, Julien; Unsain, Nicolas; Gamache, Karine; Thomas, Rhalena A.; De Leon, Andres; et al.; The X-linked inhibitor of apoptosis regulates long-term depression and learning rate; Federation of American Societies for Experimental Biology; FASEB Journal; 30; 9; 9-2016; 3083-3090  
dc.identifier.issn
0892-6638  
dc.identifier.uri
http://hdl.handle.net/11336/76265  
dc.description.abstract
Hippocampal long-term depression (LTD) is an active form of synaptic plasticity that is necessary for consolidation of spatialmemory, contextual fearmemory, and novelty acquisition. Recent studies have shown that caspases (CASPs) play an important role in NMDA receptor-dependent LTD and are involved in postsynaptic remodeling and synaptic maturation. In the present study, we examined the role of X-linked inhibitor of apoptosis (XIAP), a putative endogenous CASP inhibitor, in synaptic plasticity in the hippocampus. Analysis in acute brain slices and in cultured hippocampal neurons revealed that XIAP deletion increases CASP-3 activity, enhances α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization, sharply increases LTD, and significantly reduces synapse density. In vivo behaviors related to memorywere also altered in XIAP-/- mice, with faster acquisition of spatial object location and increased fear memory observed. Together, these results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Federation of American Societies for Experimental Biology  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Ampar  
dc.subject
Caspase-3  
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Hippocampus  
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Synaptic Activity  
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Xiap  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
The X-linked inhibitor of apoptosis regulates long-term depression and learning rate  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-04-15T18:15:21Z  
dc.identifier.eissn
1530-6860  
dc.journal.volume
30  
dc.journal.number
9  
dc.journal.pagination
3083-3090  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Bethesda  
dc.description.fil
Fil: Gibon, Julien. McGill University. Montreal Neurological Institute and Hospital; Canadá  
dc.description.fil
Fil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.description.fil
Fil: Gamache, Karine. McGill University; Canadá  
dc.description.fil
Fil: Thomas, Rhalena A.. McGill University. Montreal Neurological Institute and Hospital; Canadá  
dc.description.fil
Fil: De Leon, Andres. McGill University. Montreal Neurological Institute and Hospital; Canadá  
dc.description.fil
Fil: Johnstone, Aaron. McGill University. Montreal Neurological Institute and Hospital; Canadá  
dc.description.fil
Fil: Nader, Karim. McGill University; Canadá  
dc.description.fil
Fil: Séguéla, Philippe. McGill University. Montreal Neurological Institute and Hospital; Canadá  
dc.description.fil
Fil: Barker, Philip A.. McGill University. Montreal Neurological Institute and Hospital; Canadá  
dc.journal.title
FASEB Journal  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1096/fj.201600384R  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.fasebj.org/doi/10.1096/fj.201600384R