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dc.contributor.author
Gibon, Julien
dc.contributor.author
Unsain, Nicolas
dc.contributor.author
Gamache, Karine
dc.contributor.author
Thomas, Rhalena A.
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De Leon, Andres
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Johnstone, Aaron
dc.contributor.author
Nader, Karim
dc.contributor.author
Séguéla, Philippe
dc.contributor.author
Barker, Philip A.
dc.date.available
2019-05-14T17:54:50Z
dc.date.issued
2016-09
dc.identifier.citation
Gibon, Julien; Unsain, Nicolas; Gamache, Karine; Thomas, Rhalena A.; De Leon, Andres; et al.; The X-linked inhibitor of apoptosis regulates long-term depression and learning rate; Federation of American Societies for Experimental Biology; FASEB Journal; 30; 9; 9-2016; 3083-3090
dc.identifier.issn
0892-6638
dc.identifier.uri
http://hdl.handle.net/11336/76265
dc.description.abstract
Hippocampal long-term depression (LTD) is an active form of synaptic plasticity that is necessary for consolidation of spatialmemory, contextual fearmemory, and novelty acquisition. Recent studies have shown that caspases (CASPs) play an important role in NMDA receptor-dependent LTD and are involved in postsynaptic remodeling and synaptic maturation. In the present study, we examined the role of X-linked inhibitor of apoptosis (XIAP), a putative endogenous CASP inhibitor, in synaptic plasticity in the hippocampus. Analysis in acute brain slices and in cultured hippocampal neurons revealed that XIAP deletion increases CASP-3 activity, enhances α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization, sharply increases LTD, and significantly reduces synapse density. In vivo behaviors related to memorywere also altered in XIAP-/- mice, with faster acquisition of spatial object location and increased fear memory observed. Together, these results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Federation of American Societies for Experimental Biology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ampar
dc.subject
Caspase-3
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Hippocampus
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Synaptic Activity
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Xiap
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-04-15T18:15:21Z
dc.identifier.eissn
1530-6860
dc.journal.volume
30
dc.journal.number
9
dc.journal.pagination
3083-3090
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Gibon, Julien. McGill University. Montreal Neurological Institute and Hospital; Canadá
dc.description.fil
Fil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Gamache, Karine. McGill University; Canadá
dc.description.fil
Fil: Thomas, Rhalena A.. McGill University. Montreal Neurological Institute and Hospital; Canadá
dc.description.fil
Fil: De Leon, Andres. McGill University. Montreal Neurological Institute and Hospital; Canadá
dc.description.fil
Fil: Johnstone, Aaron. McGill University. Montreal Neurological Institute and Hospital; Canadá
dc.description.fil
Fil: Nader, Karim. McGill University; Canadá
dc.description.fil
Fil: Séguéla, Philippe. McGill University. Montreal Neurological Institute and Hospital; Canadá
dc.description.fil
Fil: Barker, Philip A.. McGill University. Montreal Neurological Institute and Hospital; Canadá
dc.journal.title
FASEB Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1096/fj.201600384R
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.fasebj.org/doi/10.1096/fj.201600384R
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