Artículo
Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease
Gupta, Shivali; Wan, Xianxu; Zago, María Paola
; Martinez Sellers, Valena C.; Silva, Trevor S.; Assiah, Dadjah; Dhiman, Monisha; Nuñez, Sonia; Petersen, John R.; Vazquez Chagoyán, Juan C.; Estrada Franco, Jose G.; Garg, Nisha Jain
Fecha de publicación:
17/01/2013
Editorial:
Public Library Of Science
Revista:
Neglected Tropical Diseases
ISSN:
1935-2735
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Chagas disease is the most common cause of congestive heart failure related deaths among young adults in the endemic areas of South and Central America and Mexico. Diagnosis and treatment of T. cruzi infection has remained difficult and challenging after 100 years of its identification. In >95% of human cases, T. cruzi infection remains undiagnosed until several years later when chronic evolution of progressive disease results in clinical symptoms associated with cardiac damage. Diagnosis generally depends on the measurement of T. cruzi'specific antibodies that can result in false positives. A conclusive diagnosis of T. cruzi infection thus often requires multiple serological tests, in combination with epidemiological data and clinical symptoms. In this study, we investigated the antibody response to TcG1, TcG2, and TcG4 in clinically characterized chagasic patients. These antigens were identified as vaccine candidates and shown to elicit protective immunity to T. cruzi and Chagas disease in experimental animals. Our data show the serology test developed using the TcGmix (multiplex ELISA) is a significantly better alternative to epimastigote extracts currently used in T. cruzi serodiagnosis or the trypomastigote lysate used in this study for comparison purposes.
Palabras clave:
Trypanosoma Cruzi
,
Diagnostic
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Articulos(IPE)
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Citación
Gupta, Shivali; Wan, Xianxu; Zago, María Paola; Martinez Sellers, Valena C.; Silva, Trevor S.; et al.; Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease; Public Library Of Science; Neglected Tropical Diseases; 7; 1; 17-1-2013; 1-10
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