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dc.contributor.author
Croci Russo, Diego Omar  
dc.contributor.author
Rabinovich, Gabriel Adrián  
dc.date.available
2016-09-12T20:11:30Z  
dc.date.issued
2014-06-25  
dc.identifier.citation
Croci Russo, Diego Omar; Rabinovich, Gabriel Adrián; Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference; Landes Bioscience; OncoImmunology; 3; 6; 25-6-2014; e29380-e29380  
dc.identifier.issn
2162-4011  
dc.identifier.uri
http://hdl.handle.net/11336/7610  
dc.description.abstract
Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complex N-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Landes Bioscience  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Galectin 1  
dc.subject
Angiogenesis  
dc.subject
Vegf  
dc.subject
Glycans  
dc.subject
Cancer Immunotherapy  
dc.subject.classification
Patología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.subject.classification
Inmunología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-06-15T19:08:26Z  
dc.journal.volume
3  
dc.journal.number
6  
dc.journal.pagination
e29380-e29380  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Austin  
dc.description.fil
Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina  
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina  
dc.journal.title
OncoImmunology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4161/onci.29380  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/www.tandfonline.com/doi/abs/10.4161/onci.29380  

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