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dc.contributor.author
Bartos, Mariana  
dc.contributor.author
Gumilar, Fernanda Andrea  
dc.contributor.author
Bras, Cristina Liliana  
dc.contributor.author
Gallegos, Cristina Eugenia  
dc.contributor.author
Giannuzzi, Leda  
dc.contributor.author
Cancela, Liliana Marina  
dc.contributor.author
Minetti, Alejandra  
dc.date.available
2016-09-09T19:26:49Z  
dc.date.issued
2015-04  
dc.identifier.citation
Bartos, Mariana; Gumilar, Fernanda Andrea; Bras, Cristina Liliana; Gallegos, Cristina Eugenia; Giannuzzi, Leda; et al.; Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development; Elsevier; Physiology And Behavior; 147; 4-2015; 205-212  
dc.identifier.issn
0031-9384  
dc.identifier.uri
http://hdl.handle.net/11336/7589  
dc.description.abstract
It is known that exposure to high concentrations of Fluoride (F) produces deleterious health effects in human population. However, in the last years it has been concluded that low concentrations of F may have adverse health effects aswell. Transplacental passage of F and its incorporation into foetal tissues has been demonstrated. Therefore, the purpose of the presentwork was to study the effects of the exposure to lowlevels of F during pregnancy and lactation on the central nervous system functionality. Wistar rats were exposed to low F concentrations (5 and 10 mg/l) during pregnancy and lactation. Sensorimotor reflexes in the each pup were analysed and the postnatal day on which both eyes and auditory canals were opened was recorded. Locomotor activity and anxiety were subsequently analysed in 45- and 90-day-old offspring by an open field test and plus maze test, respectively. A significant delay in the development of eye opening was observed in all offspring whose mothers had been exposed to the two F concentrations tested. Exposure to 5 and 10 mg/l F was also found to significantly decrease locomotor activity only in 90-day-old male and female offspring. A low index of anxiety in the young females and in all adult offspring exposed to the two F concentrations tested was also detected. Taken together, findings from the present study show that exposure to low F concentrations during pregnancy and lactation produces dysfunction in the central nervous system mechanisms which regulate motor and sensitive development, locomotor activity and anxiety.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.relation
http://hdl.handle.net/11336/185139  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Fluoride  
dc.subject
Development Exposure  
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Sensory-Motor Reflexes  
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Locomotor Activity  
dc.subject
Anxiety  
dc.subject
Rat  
dc.subject.classification
Toxicología  
dc.subject.classification
Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-05-10T14:38:30Z  
dc.journal.volume
147  
dc.journal.pagination
205-212  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina  
dc.description.fil
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina  
dc.description.fil
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina  
dc.description.fil
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina  
dc.description.fil
Fil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones En Criotecnología de Alimentos (i); Argentina  
dc.description.fil
Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina  
dc.description.fil
Fil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina  
dc.journal.title
Physiology And Behavior  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0031938415002516  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.physbeh.2015.04.044