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dc.contributor.author
Bartos, Mariana
dc.contributor.author
Gumilar, Fernanda Andrea
dc.contributor.author
Bras, Cristina Liliana
dc.contributor.author
Gallegos, Cristina Eugenia
dc.contributor.author
Giannuzzi, Leda
dc.contributor.author
Cancela, Liliana Marina
dc.contributor.author
Minetti, Alejandra
dc.date.available
2016-09-09T19:26:49Z
dc.date.issued
2015-04
dc.identifier.citation
Bartos, Mariana; Gumilar, Fernanda Andrea; Bras, Cristina Liliana; Gallegos, Cristina Eugenia; Giannuzzi, Leda; et al.; Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development; Elsevier; Physiology And Behavior; 147; 4-2015; 205-212
dc.identifier.issn
0031-9384
dc.identifier.uri
http://hdl.handle.net/11336/7589
dc.description.abstract
It is known that exposure to high concentrations of Fluoride (F) produces deleterious health effects in human population. However, in the last years it has been concluded that low concentrations of F may have adverse health effects aswell. Transplacental passage of F and its incorporation into foetal tissues has been demonstrated. Therefore, the purpose of the presentwork was to study the effects of the exposure to lowlevels of F during pregnancy and lactation on the central nervous system functionality. Wistar rats were exposed to low F concentrations (5 and 10 mg/l) during pregnancy and lactation. Sensorimotor reflexes in the each pup were analysed and the postnatal day on which both eyes and auditory canals were opened was recorded. Locomotor activity and anxiety were subsequently analysed in 45- and 90-day-old offspring by an open field test and plus maze test, respectively. A significant delay in the development of eye opening was observed in all offspring whose mothers had been exposed to the two F concentrations tested. Exposure to 5 and 10 mg/l F was also found to significantly decrease locomotor activity only in 90-day-old male and female offspring. A low index of anxiety in the young females and in all adult offspring exposed to the two F concentrations tested was also detected. Taken together, findings from the present study show that exposure to low F concentrations during pregnancy and lactation produces dysfunction in the central nervous system mechanisms which regulate motor and sensitive development, locomotor activity and anxiety.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
http://hdl.handle.net/11336/185139
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Fluoride
dc.subject
Development Exposure
dc.subject
Sensory-Motor Reflexes
dc.subject
Locomotor Activity
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Anxiety
dc.subject
Rat
dc.subject.classification
Toxicología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-10T14:38:30Z
dc.journal.volume
147
dc.journal.pagination
205-212
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.description.fil
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.description.fil
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.description.fil
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.description.fil
Fil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones En Criotecnología de Alimentos (i); Argentina
dc.description.fil
Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.journal.title
Physiology And Behavior
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0031938415002516
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.physbeh.2015.04.044
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