Mostrar el registro sencillo del ítem

dc.contributor.author
Garcia Romero, Guadalupe
dc.contributor.author
Mattioli, Guillermo Alberto
dc.contributor.author
Rosa, Diana Esther
dc.contributor.author
Díaz, Jorge Daniel
dc.contributor.author
Abeyá, María Mercedes
dc.contributor.author
Gobello, María Cristina
dc.date.available
2019-04-30T17:27:46Z
dc.date.issued
2012-06
dc.identifier.citation
Garcia Romero, Guadalupe; Mattioli, Guillermo Alberto; Rosa, Diana Esther; Díaz, Jorge Daniel; Abeyá, María Mercedes; et al.; A Single Administration of the GnRH Antagonist Acyline Inhibits Basal and GnRH-Stimulated Serum Testosterone Concentrations in Male Dogs; Wiley Blackwell Publishing, Inc; Reproduction in Domestic Animals; 47; 3; 6-2012
dc.identifier.issn
0936-6768
dc.identifier.uri
http://hdl.handle.net/11336/75355
dc.description.abstract
The objective of this study was to describe testosterone (T) response to GnRH challenge in antagonist-treated dogs over a 30-day period. Eight mongrel dogs were randomly assigned to either the GnRH antagonist acyline 330μg/kg sc (ACY; n=4) or a placebo group (PLA; n=4). The dogs were serially challenged with the GnRH agonist, buserelin 0.2μg/kg sc on days -1, 1, 3, 7, 10, 14, 21 and 30. On these days, blood samples for T determinations were collected before (-30min) and 60, 120 and 180min after the agonist injection. Basal (-30min) and post-GnRH agonist stimulation T values were compared by anova for repeated measures. Before treatments (day -1), there were no differences in basal T serum concentrations between groups (p>0.1). After treatments, basal T showed a significant interaction between treatment and day (p<0.05). Furthermore, when both groups were analysed independently, basal T varied in the ACY (p<0.01) but not in the PLA group (p>0.1). On day -1, before treatments, the stimulation tests had only a time effect (p=0.05) although on days 1 (p<0.01), 3 (p<0.01), 7 (p<0.01), 10 (p<0.01) and 14 (p<0.05), the response to the agonist differed between groups, becoming similar on days 21 (p>0.05) and 30 (p>0.05). It was concluded that, in dogs, a single administration of the GnRH antagonist prevented canine gonadal axis to physiologically respond to agonistic challenge during 14 days.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gnrh
dc.subject
Acyline
dc.subject
Testoterone
dc.subject
Dog
dc.subject.classification
Otras Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
A Single Administration of the GnRH Antagonist Acyline Inhibits Basal and GnRH-Stimulated Serum Testosterone Concentrations in Male Dogs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-04-26T18:25:24Z
dc.journal.volume
47
dc.journal.number
3
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Garcia Romero, Guadalupe. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Laboratorio de Nutrición Mineral y Fisiología Reproductiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Mattioli, Guillermo Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Laboratorio de Nutrición Mineral y Fisiología Reproductiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rosa, Diana Esther. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Laboratorio de Nutrición Mineral y Fisiología Reproductiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Díaz, Jorge Daniel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Laboratorio de Nutrición Mineral y Fisiología Reproductiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Abeyá, María Mercedes. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Laboratorio de Nutrición Mineral y Fisiología Reproductiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gobello, María Cristina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Laboratorio de Nutrición Mineral y Fisiología Reproductiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Reproduction in Domestic Animals
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1439-0531.2011.01898.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1439-0531.2011.01898.x


Archivos asociados

Documento no disponible

Comunidades y colecciones

Mostrar el registro sencillo del ítem