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dc.contributor.author
Dharma Rao, Bhaskara D.
dc.contributor.author
Bhandary, Subhrajyoti
dc.contributor.author
Chopra, Deepak
dc.contributor.author
Venugopala, Katharigatta N.
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Gleiser, Raquel M.
dc.contributor.author
Kasumbwe, Kabange
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Odhav, Bharti
dc.date.available
2019-04-30T17:26:28Z
dc.date.issued
2017-09
dc.identifier.citation
Dharma Rao, Bhaskara D.; Bhandary, Subhrajyoti; Chopra, Deepak; Venugopala, Katharigatta N.; Gleiser, Raquel M.; et al.; Synthesis and characterization of a novel series of 1,4-dihydropyridine analogues for larvicidal activity against Anopheles arabiensis; Wiley Blackwell Publishing, Inc; Chemical Biology & Drug Design; 90; 3; 9-2017; 397-405
dc.identifier.issn
1747-0277
dc.identifier.uri
http://hdl.handle.net/11336/75352
dc.description.abstract
The new-fangled bis(4-substituted benzyl) 4-(4-substitued phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivatives were synthesized by the union of substituted aryl aldehyde, tert-butyl acetoacetate, ammonium carbonate with 4-substituted benzyl alcohol via Hantzsch ester synthesis in aqueous medium under catalyst-free conditions. The newly synthesized compounds were characterized by spectroscopic techniques such as IR, NMR (1H and 13C), ESI mass, elemental analysis, and single-crystal X-ray diffraction. The characterized title compounds were evaluated for the larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay method using Temephos as standard at 4 μg/ml. The title compounds bis(4-methoxybenzyl) 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate and bis(4-chlorobenzyl) 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate exhibited promising larvicidal activity at 65.6% and 72.2%, respectively, when compared with the standard compound at 98.9%.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Crystallography
dc.subject
Dihydropyridine
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Hantzsch Synthesis
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Larvicidal Activity.
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Multi-Component Reaction
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Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Synthesis and characterization of a novel series of 1,4-dihydropyridine analogues for larvicidal activity against Anopheles arabiensis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-04-15T18:30:23Z
dc.journal.volume
90
dc.journal.number
3
dc.journal.pagination
397-405
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Dharma Rao, Bhaskara D.. Indian Institute of Science Education and Research Bhopal; India
dc.description.fil
Fil: Bhandary, Subhrajyoti. Indian Institute of Science Education and Research Bhopal; India
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Fil: Chopra, Deepak. Indian Institute of Science Education and Research Bhopal; India
dc.description.fil
Fil: Venugopala, Katharigatta N.. Durban University of Technology; India
dc.description.fil
Fil: Gleiser, Raquel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Kasumbwe, Kabange. Durban University of Technology; India
dc.description.fil
Fil: Odhav, Bharti. Durban University of Technology; India
dc.journal.title
Chemical Biology & Drug Design
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/cbdd.12957
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.12957


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