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dc.contributor.author
Ghietto, Lucía María
dc.contributor.author
Toigo D´angelo, Natalia Gabriela
dc.contributor.author
Viale, Franco Agustín
dc.contributor.author
Adamo, Maria Pilar
dc.date.available
2019-04-30T14:35:53Z
dc.date.issued
2017-10
dc.identifier.citation
Ghietto, Lucía María; Toigo D´angelo, Natalia Gabriela; Viale, Franco Agustín; Adamo, Maria Pilar; Human bocavirus 1 infection of CACO-2 cell line cultures; Academic Press Inc Elsevier Science; Virology; 510; 10-2017; 273-280
dc.identifier.issn
0042-6822
dc.identifier.uri
http://hdl.handle.net/11336/75313
dc.description.abstract
Human bocavirus 1 (HBoV1) is a parvovirus associated with pneumonia in infants. It has been detected in different tissues, including colorectal tumors. In this study, we investigated whether Caco-2 cell line, derived from human colon cancer, can be utilized as a model for HBoV1 replication. We demonstrate HBoV1 replication in Caco-2 cultures supplemented with DEAE-dextran after inoculation with respiratory material from infected patients presenting with acute respiratory infection. A viral cycle of rapid development is displayed. However, in spite of HBoV1 DNA 4-fold increment in the supernatants and monolayers by day 1, evidencing that the system allows the virus genome replication after the entry occurred, infectious progeny particles were not produced. These results are consistent with an infection that is limited to a single growth cycle, which can be associated to mutations in the NS1 and VP1/VP2 regions of HBoV1 genome. Further research will contribute to fully elucidate these observations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Isolation
dc.subject
Primate Bocaparvovirus 1
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Sequence
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Virus Replication
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Human bocavirus 1 infection of CACO-2 cell line cultures
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-04-15T18:24:35Z
dc.journal.volume
510
dc.journal.pagination
273-280
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Ghietto, Lucía María. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología "Dr. J. M. Vanella"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Toigo D´angelo, Natalia Gabriela. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología "Dr. J. M. Vanella"; Argentina
dc.description.fil
Fil: Viale, Franco Agustín. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología "Dr. J. M. Vanella"; Argentina
dc.description.fil
Fil: Adamo, Maria Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología "Dr. J. M. Vanella"; Argentina
dc.journal.title
Virology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.virol.2017.07.034
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0042682217302532
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