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dc.contributor.author
Vallejo, Mariana Guadalupe
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Loyola, Sebastián
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Contreras, Darwin
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Ugarte, Gonzalo
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Cifuente, Diego Alberto
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Ortega, María Gabriela
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Cabrera, Jose Luis
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Zeise, Marc
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Tonn, Carlos Eugenio
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Carreño, Mario
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Delgado, Ricardo
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Morales, Bernardo
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Agnese, Mariel
dc.date.available
2016-09-07T19:13:14Z
dc.date.issued
2014-03
dc.identifier.citation
Vallejo, Mariana Guadalupe; Loyola, Sebastián; Contreras, Darwin; Ugarte, Gonzalo; Cifuente, Diego Alberto; et al.; A new semisynthetic derivative of sauroine induces LTP in hippocampal slices and improves learning performance in the Morris Water Maze; Wiley; Journal of Neurochemistry; 129; 5; 3-2014; 864-876
dc.identifier.issn
1471-4159
dc.identifier.uri
http://hdl.handle.net/11336/7516
dc.description.abstract
Two semisynthetic acetyl derivatives of the alkaloid sauroine from Huperzia saururus, monoacetyl sauroine, and diacetyl sauroine (DAS) were obtained and their chemical structures were analyzed by NMR. While monoacetyl sauroine is the typical product of acetylation, DAS is an unexpected derivative related to the keto-enol formation of sauroine. Recordings of field excitatory post-synaptic potentials from the CA1 region of rat hippocampal slices showed that only DAS acutely applied induced chemical long-term potentiation (LTP) in a dose-dependent manner with an EC50 of 1.15 0.09 lM. This effectwasblockedby10 lMD(-)-2-amino-5-phosphonopentanoic acid (AP5), suggesting dependence on the NMDA receptor. DAS significantly increased NMDA receptor-dependent excitatory post-synaptic currents without affecting a-amino- 3-hydroxy-5-methylisoxazole-4-propionate receptor-dependent currents. Repetitive administration of DAS improved visuospatial learning in the Morris Water Maze. In slices from rats tested in the Morris Water Maze, LTP resulting from electrical synaptic stimulation was 2.5 times larger than in controls. Concentration of DAS measured in the brain after repetitive administration was 29.5 lM. We conclude that slices perfused with DAS display a robust NMDA receptor-dependent chemical LTP. During chronic treatment, DAS enhances
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application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Learning And Memory
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Long Term Potentiation
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Lycopodium Alkaloids
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Metaplasticity
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Sauroine Acetylation
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Synaptic Plasticity
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A new semisynthetic derivative of sauroine induces LTP in hippocampal slices and improves learning performance in the Morris Water Maze
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
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info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-16T20:09:18Z
dc.journal.volume
129
dc.journal.number
5
dc.journal.pagination
864-876
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Vallejo, Mariana Guadalupe. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
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Fil: Loyola, Sebastián. Universidad de Santiago de Chile; Chile
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Fil: Contreras, Darwin. Universidad de Santiago de Chile; Chile
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Fil: Ugarte, Gonzalo. Universidad de Santiago de Chile; Chile
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Fil: Cifuente, Diego Alberto. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
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Fil: Ortega, María Gabriela. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina
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Fil: Cabrera, Jose Luis. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina
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Fil: Zeise, Marc. Universidad de Santiago de Chile; Chile
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Fil: Tonn, Carlos Eugenio. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones en Tecnología Química; Argentina
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Fil: Carreño, Mario. Universidad de Santiago de Chile; Chile
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Fil: Delgado, Ricardo. Universidad de Santiago de Chile; Chile
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Fil: Morales, Bernardo. Universidad de Santiago de Chile; Chile
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Fil: Agnese, Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
dc.journal.title
Journal of Neurochemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jnc.12685/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jnc.12685
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