Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework

Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 lM, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 lM, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs.

Palabras clave: Coumarins , Reverse Transcriptase , Polymerase , Molecular Target , Inhibition

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)

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URI: http://hdl.handle.net/11336/7494

URL: http://www.sciencedirect.com/science/article/pii/S0960894X13014881

DOI: http://dx.doi.org/10.1016/j.bmcl.2013.12.104

Colecciones

Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS

Articulos(INTEQUI)
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA

Citación

Garro, Hugo Alejandro; Manzur, Maria Jimena; Ciuffo, Gladys Maria; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework; Elsevier; Bioorganic & Medicinal Chemistry Letters; 24; 3; 1-2014; 760-764

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