Artículo
Tumor-specific MAGE proteins as regulators of p53 function
Ladelfa, Maria Fatima
; Peche, Leticia Yamila; Toledo, Maria Fernanda
; Laiseca, Julieta Eva
; Schneider, Claudio; Monte, Martin
Fecha de publicación:
12/2012
Editorial:
Elsevier Ireland
Revista:
Cancer Letters
ISSN:
0304-3835
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
Palabras clave:
Anticancer Therapies
,
Mage
,
P53
,
Transcriptional Inhibition
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Ladelfa, Maria Fatima; Peche, Leticia Yamila; Toledo, Maria Fernanda; Laiseca, Julieta Eva; Schneider, Claudio; et al.; Tumor-specific MAGE proteins as regulators of p53 function; Elsevier Ireland; Cancer Letters; 325; 1; 12-2012; 11-17
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