Artículo
IPSCs: A Minireview from bench to bed, including organoids and the crispr system
Fecha de publicación:
01/2016
Editorial:
Hindawi Publishing Corporation
Revista:
Stem Cells International
ISSN:
1687-9678
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a whole new animal. The reprogramming strategies based on patient-derived cells should make the development of clinical applications of cell based therapy much more straightforward. Here, we analyze the current state, opportunities, and challenges of iPSCs from bench to bed, including organoids and the CRISPR system.
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Citación
Orqueda, Andres Javier; Giménez, Carla Alejandra; Pereyra Bonnet, Federico Alberto; IPSCs: A Minireview from bench to bed, including organoids and the crispr system; Hindawi Publishing Corporation; Stem Cells International; 2016; 1-2016; 1-9
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