Artículo
Alterations of the extracellular matrix of lung during zinc deficiency
Biaggio, Veronica Silvina
; Salvetti, Natalia Raquel
; Perez Chaca, Maria Valeria
; Valdez, Susana Ruth
; Ortega, Hugo Hector
; Gimenez, Maria Sofia
; Gomez, Nidia Noemí
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Fecha de publicación:
07/2012
Editorial:
Cambridge University Press
Revista:
British Journal of Nutrition
ISSN:
0007-1145
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Suboptimal intake of Zn is one of the most common nutritional problems worldwide. Previously, we have shown that Zn deficiency (ZD) produces oxidative and nitrosative stress in the lung of rats. We analyse the effect of moderate ZD on the expression of several intermediate filaments of the cytoskeleton, as well as the effect of restoring Zn during the refeeding period. Adult male rats were divided into three groups: Zn-adequate control (CO) group; ZD group; Zn-refeeding group. CerbB-2 and proliferating cell nuclear antigen (PCNA) expression was increased in the ZD group while the other parameters did not change. During the refeeding time, CerbB-2, cytokeratins, vimentin and PCNA immunostaining was higher than that in the CO group. The present findings indicate that the overexpression of some markers could lead to the fibrotic process in the lung. Perhaps ZD implications must be taken into account in health interventions because an inflammation environment is associated with ZD in the lung.
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Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Citación
Biaggio, Veronica Silvina; Salvetti, Natalia Raquel; Perez Chaca, Maria Valeria; Valdez, Susana Ruth; Ortega, Hugo Hector; et al.; Alterations of the extracellular matrix of lung during zinc deficiency; Cambridge University Press; British Journal of Nutrition; 108; 1; 7-2012; 62-70
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