Artículo
On cell resistance and immune response time lag in a model for the HIV infection
Solovey, Guillermo
; Peruani San Román, Fernando Miguel; Ponce Dawson, Silvina Martha
; Dos Santos, Rita Maria Zorzenon
Fecha de publicación:
12/2004
Editorial:
Elsevier Science
Revista:
Physica A: Statistical Mechanics and its Applications
ISSN:
0378-4371
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Recently, a cellular automata model has been introduced (Phys. Rev. Lett. 87 (2001) 168102) to describe the spread of the HIV infection among target cells in lymphoid tissues. The model reproduces qualitatively the entire course of the infection displaying, in particular, the two time scales that characterize its dynamics. In this work, we investigate the robustness of the model against changes in three of its parameters. Two of them are related to the resistance of the cells to get infected. The other one describes the time interval necessary to mount specific immune responses. We have observed that an increase of the cell resistance, at any stage of the infection, leads to a reduction of the latency period, i.e., of the time interval between the primary infection and the onset of AIDS. However, during the early stages of the infection, when the cell resistance increase is combined with an increase in the initial concentration of infected cells, the original behavior is recovered. Therefore we find a long and a short latency regime (eight and one year long, respectively) depending on the value of the cell resistance. We have obtained, on the other hand, that changes on the parameter that describes the immune system time lag affects the time interval during which the primary infection occurs. Using different extended versions of the model, we also discuss how the two-time scale dynamics is affected when we include inhomogeneities on the cells properties, as for instance, on the cell resistance or on the time interval to mount specific immune responses. © 2004 Elsevier B.V. All rights reserved.
Palabras clave:
Cellular Automata
,
Dynamical Systems
,
Hiv Infection
,
Pattern Formation
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Colecciones
Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Solovey, Guillermo; Peruani San Román, Fernando Miguel; Ponce Dawson, Silvina Martha; Dos Santos, Rita Maria Zorzenon; On cell resistance and immune response time lag in a model for the HIV infection; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 343; 1-4; 12-2004; 543-556
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