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dc.contributor.author
Abarbanel, Henry D. I.
dc.contributor.author
Gibb, Leif
dc.contributor.author
Mindlin, Bernardo Gabriel
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dc.contributor.author
Rabinovich, M.I.
dc.contributor.author
Talathi, Sachin
dc.date.available
2019-04-08T16:00:58Z
dc.date.issued
2004-12
dc.identifier.citation
Abarbanel, Henry D. I.; Gibb, Leif; Mindlin, Bernardo Gabriel; Rabinovich, M.I.; Talathi, Sachin; Spike timing and synaptic plasticity in the premotor pathway of birdsong; Springer; Biological Cybernetics.; 91; 3; 12-2004; 159-167
dc.identifier.issn
0340-1200
dc.identifier.uri
http://hdl.handle.net/11336/73386
dc.description.abstract
The neural circuits of birdsong appear to utilize specific time delays in their operation. In particular, the anterior forebrain pathway (AFP) is implicated in an approximately 40- to 50- ms time delay, ΔT, playing a role in the relative timing of premotor signals from the nucleus HVc to the nucleus robust nucleus of the archistratium (RA) and control/learning signals from the nucleus lateral magnocellular nucleus of the anterior neostratium (lMAN) to RA. Using a biophysical model of synaptic plasticity based on experiments on mammalian hippocampal and neocortical pyramidal neurons, we propose an understanding of this ≈ 40- to 50- ms delay. The biophysical model describes the influence of Ca2+ influx into the postsynaptic RA cells through NMDA and AMPA receptors and the induction of LTP and LTD through complex metabolic pathways. The delay, ΔT, between HVc → RA premotor signals and lMAN → RA control/learning signals plays an essential role in determining if synaptic plasticity is induced by signaling from each pathway into RA. If ΔT is substantially larger than 40 ms, no plasticity is induced. If ΔT is much less than 40 ms, only potentiation is expected. If ΔT≈ 40 ms, the sign of synaptic plasticity is sensitive to ΔT. Our results suggest that changes in ΔT may influence learning and maintenance of birdsong. We investigate the robustness of this result to noise and to the removal of the Ca2+ contribution from lMAN → RA NMDA receptors. © Springer-Verlag 2004.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Astronomía
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Spike timing and synaptic plasticity in the premotor pathway of birdsong
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-04-05T18:25:56Z
dc.journal.volume
91
dc.journal.number
3
dc.journal.pagination
159-167
dc.journal.pais
Alemania
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Abarbanel, Henry D. I.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Gibb, Leif. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Mindlin, Bernardo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
dc.description.fil
Fil: Rabinovich, M.I.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Talathi, Sachin. University of California at San Diego; Estados Unidos
dc.journal.title
Biological Cybernetics.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00422-004-0495-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00422-004-0495-1
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