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dc.contributor.author
Wilson Rodriguez, Carlos
dc.contributor.author
Munoz-Palma, Ernesto
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Henriquez, Daniel R.
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Palmisano, Ilaria
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Nuñez, Marco Tulio
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Di Giovanni, Simone
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González Billault, Christian
dc.date.available
2019-03-28T18:18:52Z
dc.date.issued
2016-10
dc.identifier.citation
Wilson Rodriguez, Carlos; Munoz-Palma, Ernesto; Henriquez, Daniel R.; Palmisano, Ilaria; Nuñez, Marco Tulio; et al.; A feed-forward mechanism involving the NOX complex and RyR-mediated ca2 + release during axonal specification; Society for Neuroscience; Journal of Neuroscience; 36; 43; 10-2016; 11107-11119
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/72755
dc.description.abstract
Physiological levels of ROS support neurite outgrowth and axonal specification, but the mechanisms by which ROS are able to shape neurons remain unknown. Ca2 +, a broad intracellular second messenger, promotes both Rac1 activation and neurite extension. Ca2 + release from the endoplasmic reticulum, mediated by both the IP3R1 and ryanodine receptor (RyR) channels, requires physiological ROS levels that are mainly sustained by the NADPH oxidase (NOX) complex. In this work, we explore the contribution of the link between NOX and RyR-mediated Ca2 + release toward axonal specification of rat hippocampal neurons. Using genetic approaches, we find thatNOXactivation promotes both axonal development and Rac1 activation through a RyR-mediated mechanism, which in turn activates NOX through Rac1, one of the NOX subunits. Collectively, these data suggest a feedforward mechanism that integrates both NOX activity and RyR-mediated Ca2 + release to support cellular mechanisms involved in axon development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Actin Cytoskeleton
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Axon Development
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Calcium Signaling
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Nadph Oxidase
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Neuronal Differentiation
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Reactive Oxygen Species
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A feed-forward mechanism involving the NOX complex and RyR-mediated ca2 + release during axonal specification
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-21T14:17:37Z
dc.identifier.eissn
1529-2401
dc.journal.volume
36
dc.journal.number
43
dc.journal.pagination
11107-11119
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Wilson Rodriguez, Carlos. Universidad de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
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Fil: Munoz-Palma, Ernesto. Universidad de Chile; Chile
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Fil: Henriquez, Daniel R.. Universidad de Chile; Chile
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Fil: Palmisano, Ilaria. Imperial College London; Reino Unido
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Fil: Nuñez, Marco Tulio. Universidad de Chile; Chile
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Fil: Di Giovanni, Simone. Imperial College London; Reino Unido. University of Tuebingen; Alemania
dc.description.fil
Fil: González Billault, Christian. Universidad de Chile; Chile
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/36/43/11107
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.1455-16.2016